Small round cell sarcomas
Undifferentiated small round cell sarcomas (SRCSs) of bone and soft tissue comprise a
heterogeneous group of highly aggressive tumours associated with a poor prognosis …
heterogeneous group of highly aggressive tumours associated with a poor prognosis …
A comprehensive overview of small-molecule androgen receptor degraders: Recent progress and future perspectives
S Ha, G Luo, H Xiang - Journal of medicinal chemistry, 2022 - ACS Publications
Prostate cancer (PC), the second most prevalent malignancy in men worldwide, has been
proven to depend on the aberrant activation of androgen receptor (AR) signaling. Long-term …
proven to depend on the aberrant activation of androgen receptor (AR) signaling. Long-term …
[HTML][HTML] WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation
K Song, H Sun, B Tu, Y Zhou, LC Lin, ZY Liu, R Li… - Iscience, 2023 - cell.com
Dysregulated lipid metabolism occurs in pathological processes characterized by cell
proliferation and migration. Nonetheless, the mechanism of increased mitochondrial lipid …
proliferation and migration. Nonetheless, the mechanism of increased mitochondrial lipid …
Patient-derived organoids as a promising tool for multimodal management of sarcomas
Simple Summary Patient-derived sarcoma organoids (PDSOs) are a new and promising tool
for treating sarcomas, a type of cancer that affects the body's connective tissues. These …
for treating sarcomas, a type of cancer that affects the body's connective tissues. These …
EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors
EWS fusion oncoproteins underlie several human malignancies including Desmoplastic
Small Round Cell Tumor (DSRCT), an aggressive cancer driven by EWS-WT1 fusion …
Small Round Cell Tumor (DSRCT), an aggressive cancer driven by EWS-WT1 fusion …
Desmoplastic small round cell tumor: From genomics to targets, potential paths to future therapeutics
JW Magrath, M Espinosa-Cotton… - Frontiers in Cell and …, 2024 - frontiersin.org
Desmoplastic Small Round Cell Tumor (DSRCT) is a highly aggressive pediatric cancer
caused by a reciprocal translocation between chromosomes 11 and 22, leading to the …
caused by a reciprocal translocation between chromosomes 11 and 22, leading to the …
Mesenchymal tumours of the pleura: review and update
V Rerkpichaisuth, YP Hung - Histopathology, 2024 - Wiley Online Library
Primary mesenchymal tumours of the pleura are uncommon and can be diagnostically
challenging due to their overlapping histopathologic and immunophenotypic features …
challenging due to their overlapping histopathologic and immunophenotypic features …
Enzalutamide induces cytotoxicity in desmoplastic small round cell tumor independent of the androgen receptor
Abstract Desmoplastic Small Round Cell Tumor (DSRCT) is a rare, pediatric cancer caused
by the EWSR1:: WT1 fusion protein. DSRCT predominantly occurs in males, which comprise …
by the EWSR1:: WT1 fusion protein. DSRCT predominantly occurs in males, which comprise …
Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in DSRCTs
C Henon, J Vibert, T Eychenne, N Gruel… - Cell Reports …, 2024 - cell.com
Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive sarcoma driven by the
EWSR1:: WT1 chimeric transcription factor. Despite this unique oncogenic driver, DSRCT …
EWSR1:: WT1 chimeric transcription factor. Despite this unique oncogenic driver, DSRCT …
[HTML][HTML] Molecular profiling in desmoplastic small round cell tumours
Desmoplastic small round cell tumour (DSRCT) is an ultra-rare soft tissue sarcoma that is
characterised by aggressive disease and dismal patient outcomes. Despite multi-modal …
characterised by aggressive disease and dismal patient outcomes. Despite multi-modal …