Safety and efficacy of phage therapy in difficult-to-treat infections: a systematic review
S Uyttebroek, B Chen, J Onsea… - The Lancet Infectious …, 2022 - thelancet.com
According to the latest reports from WHO, the incidence of antibiotic-resistant bacterial
infections is increasing worldwide, resulting in increased morbidity and mortality and a rising …
infections is increasing worldwide, resulting in increased morbidity and mortality and a rising …
Considerations for the use of phage therapy in clinical practice
Increasing antimicrobial resistance and medical device-related infections have led to a
renewed interest in phage therapy as an alternative or adjunct to conventional …
renewed interest in phage therapy as an alternative or adjunct to conventional …
[HTML][HTML] The safety and toxicity of phage therapy: a review of animal and clinical studies
Increasing rates of infection by antibiotic resistant bacteria have led to a resurgence of
interest in bacteriophage (phage) therapy. Several phage therapy studies in animals and …
interest in bacteriophage (phage) therapy. Several phage therapy studies in animals and …
Safety of bacteriophage therapy in severe Staphylococcus aureus infection
A Petrovic Fabijan, RCY Lin, J Ho, S Maddocks… - Nature …, 2020 - nature.com
In this single-arm non-comparative trial, 13 patients in an Australian hospital with severe
Staphylococcus aureus infections were intravenously administered a good manufacturing …
Staphylococcus aureus infections were intravenously administered a good manufacturing …
[HTML][HTML] Phage therapy in the resistance era: where do we stand and where are we going?
Purpose Widespread antibiotic-resistant bacteria are threatening the arsenal of existing
antibiotics. Not only are antibiotics less likely to be effective today, but their extensive use …
antibiotics. Not only are antibiotics less likely to be effective today, but their extensive use …
[HTML][HTML] Phage cocktail development for bacteriophage therapy: toward improving spectrum of activity breadth and depth
Phage therapy is the use of bacterial viruses as antibacterial agents. A primary
consideration for commercial development of phages for phage therapy is the number of …
consideration for commercial development of phages for phage therapy is the number of …
[HTML][HTML] Translating phage therapy into the clinic: Recent accomplishments but continuing challenges
A Petrovic Fabijan, J Iredell, K Danis-Wlodarczyk… - Plos …, 2023 - journals.plos.org
Phage therapy is a medical form of biological control of bacterial infections, one that uses
naturally occurring viruses, called bacteriophages or phages, as antibacterial agents …
naturally occurring viruses, called bacteriophages or phages, as antibacterial agents …
Current challenges and future opportunities of phage therapy
Antibiotic resistance is a major public health challenge worldwide, whose implications for
global health might be devastating if novel antibacterial strategies are not quickly …
global health might be devastating if novel antibacterial strategies are not quickly …
[HTML][HTML] Staphylococcus aureus Vaccine Research and Development: The Past, Present and Future, Including Novel Therapeutic Strategies
J Clegg, E Soldaini, RM McLoughlin… - Frontiers in …, 2021 - frontiersin.org
Staphylococcus aureus is one of the most important human pathogens worldwide. Its high
antibiotic resistance profile reinforces the need for new interventions like vaccines in …
antibiotic resistance profile reinforces the need for new interventions like vaccines in …
[HTML][HTML] The safety and efficacy of phage therapy: a systematic review of clinical and safety trials
HJ Stacey, S De Soir, JD Jones - Antibiotics, 2022 - mdpi.com
Trials of phage therapy have not consistently reported efficacy. This contrasts with promising
efficacy rates from a sizeable and compelling body of observational literature. This …
efficacy rates from a sizeable and compelling body of observational literature. This …