Some individuals with a particular disease-causing mutation or genotype fail to express
most if not all features of the disease in question, a phenomenon that is known as 'reduced …

Chronic pancreatitis (CP) is an inflammatory disease of the pancreas characterized by
progressive fibrotic destruction of the pancreatic secretory parenchyma. Despite the …

Objective To determine the clinical presentation, diagnostic variables, risk factors, and
disease burden in children with chronic pancreatitis. Study design We performed a cross …

OBJECTIVES: Hereditary pancreatitis (HP), an autosomal dominant disease typically
caused by mutations inPRSS1, has a broad range of clinical characteristics and high …

Genetic risk in chronic pancreatitis: the misfolding-depende... : Current Opinion in
Gastroenterology Genetic risk in chronic pancreatitis: the misfolding-dependent pathway …

Individuals with recurrent acute and chronic pancreatitis (CP) may have an inherited
predisposition to the development of the disease. Pancreatitis in the setting of a significant …

Mutations in human cationic trypsinogen (PRSS1) cause autosomal dominant hereditary
pancreatitis. Increased intrapancreatic autoactivation of trypsinogen mutants has been …

Hereditary pancreatitis is a rare cause of chronic pancreatitis. The prevalence was
evaluated to 0.3/100000 in Western Countries. Genetic disorders are due to mutations of the …

Background Hereditary pancreatitis (HP) is a rare cause of chronic pancreatitis. We here
report a nationwide survey to clarify the epidemiological, genetic, and clinical features of HP …

Objective Pancreatic cancer (PC) is the fourth leading cause of cancer death worldwide,
symptoms are few and diffuse, and when the diagnosis has been made only 10–15% would …