The lacrimal film has attracted increasing interest in the last decades as a potential source of
biomarkers of physiopathological states, due to its accessibility, moderate complexity, and …

Significant technical advancements in phosphopeptide enrichment have enabled the
identification of thousands of p-peptides (mono and multiply phosphorylated) in a single …

Mass spectrometry-based proteomics is constantly challenged by the presence of
contaminant background signals. In particular, protein contaminants from reagents and …

Drug transporter expression in tissues (in vivo) usually differs from that in cell lines used to
measure transporter activity (in vitro). Therefore, quantification of transporter expression in …

Considering absence of invasiveness and side effects, tears emerge as a particularly
attractive fluid for biomarker discovery and therefore for daily clinical use. However, to date …

Gel-free bottom-up shotgun proteomics is the principal methodological platform for the state-
of-the-art proteome research. This methodology assumes quantitative isolation of the total …

Protein quantification data on drug metabolizing enzymes and transporters (collectively
referred as DMET proteins) in human tissues are useful in predicting interindividual …

Single-cell multi-omics analysis can provide comprehensive insights to study cell-to-cell
heterogeneity in normal and disease physiology. However, due to the lack of amplification …

Background Pancreatic cancer is a heterogenous disease with a poor prognosis. This study
aimed to discover and validate prognostic tissue biomarkers in pancreatic cancer using a …

Cellulose is synthesized at the plasma membrane by cellulose synthase complexes (CSCs)
containing cellulose synthases (CESAs). Genetic analysis and CESA isoform quantification …