Preterm infants are at increased risk for invasive neonatal bacterial infections. S.
epidermidis, a ubiquitous skin commensal, is a major cause of late-onset neonatal sepsis …

Background The design of computerized systems able to support automated detection of
threatening conditions in critically ill patients such as systemic inflammatory response …

Objective Current knowledge on the global burden of infant sepsis is limited to population-
level data. We aimed to summarize global case fatality rates (CFRs) of young infants with …

Conclusions It is impossible to say with certainty that “culture-negative” sepsis does not
exist. Myriad observational data support the experience of an infant with clinical signs of …

Infectious diseases pose a fatal risk to neonates. Timely and accurate pathogen detection is
crucial for proper clinical diagnosis and therapeutic strategies. Limited sample volumes from …

Abstract Neonatal sepsis (NS) kills 750,000 infants every year. Effectively treating NS
requires timely diagnosis and antimicrobial therapy matched to the causative pathogens, but …

Background: Culture-negative late-onset sepsis (LOS) is commonly diagnosed in neonatal
intensive care units, while the outcomes of neonatal culture-negative LOS are not reported …

Outer membrane vesicles (OMVs) are lipid-membrane-bounded nanoparticles that are
released from Gram-negative bacteria via vesiculation of the outer membrane. They have …

Polymicrobial sepsis is associated with worse patient outcomes than monomicrobial sepsis.
Routinely used culture-dependent microbiological diagnostic techniques have low …

Background Blood cultures remain the gold standard investigation for the diagnosis of
bloodstream infections. In many locations, quality-assured processing of positive blood …