Optical spectroscopy for in vivo medical diagnosis—a review of the state of the art and future perspectives
When light is incident to a biological tissue surface, combinations of optical processes occur,
such as reflection, absorption, elastic and non-elastic scattering, and fluorescence. Analysis …
such as reflection, absorption, elastic and non-elastic scattering, and fluorescence. Analysis …
Mesoscopic fluorescence lifetime imaging: Fundamental principles, clinical applications and future directions
Fluorescence lifetime imaging (FLIm) is an optical spectroscopic imaging technique capable
of real‐time assessments of tissue properties in clinical settings. Label‐free FLIm is sensitive …
of real‐time assessments of tissue properties in clinical settings. Label‐free FLIm is sensitive …
The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition
Abstract α-Synuclein (αS) is a presynaptic disordered protein whose aberrant aggregation is
associated with Parkinson's disease. The functional role of αS is still debated, although it …
associated with Parkinson's disease. The functional role of αS is still debated, although it …
Intraoperative margin assessment in oral and oropharyngeal cancer using label-free fluorescence lifetime imaging and machine learning
Objective: To demonstrate the diagnostic ability of label-free, point-scanning, fiber-based
Fluorescence Lifetime Imaging (FLIm) as a means of intraoperative guidance during oral …
Fluorescence Lifetime Imaging (FLIm) as a means of intraoperative guidance during oral …
Investigations on average fluorescence lifetimes for visualizing multi-exponential decays
Intensity-and amplitude-weighted average lifetimes, denoted as τ I and τ A hereafter, are
useful indicators for revealing Förster resonance energy transfer (FRET) or fluorescence …
useful indicators for revealing Förster resonance energy transfer (FRET) or fluorescence …
Autofluorescence lifetime augmented reality as a means for real-time robotic surgery guidance in human patients
Due to loss of tactile feedback the assessment of tumor margins during robotic surgery is
based only on visual inspection, which is neither significantly sensitive nor specific. Here we …
based only on visual inspection, which is neither significantly sensitive nor specific. Here we …
Real-time diagnosis and visualization of tumor margins in excised breast specimens using fluorescence lifetime imaging and machine learning
Tumor-free surgical margins are critical in breast-conserving surgery. In up to 38% of the
cases, however, patients undergo a second surgery since malignant cells are found at the …
cases, however, patients undergo a second surgery since malignant cells are found at the …
Real‐time augmented reality for delineation of surgical margins during neurosurgery using autofluorescence lifetime contrast
A Alfonso‐Garcia, J Bec… - Journal of …, 2020 - Wiley Online Library
Current clinical brain imaging techniques used for surgical planning of tumor resection lack
intraoperative and real‐time feedback; hence surgeons ultimately rely on subjective …
intraoperative and real‐time feedback; hence surgeons ultimately rely on subjective …
Design and evaluation of a device for fast multispectral time-resolved fluorescence spectroscopy and imaging
DR Yankelevich, D Ma, J Liu, Y Sun, Y Sun… - Review of Scientific …, 2014 - pubs.aip.org
The application of time-resolved fluorescence spectroscopy (TRFS) to in vivo tissue
diagnosis requires a method for fast acquisition of fluorescence decay profiles in multiple …
diagnosis requires a method for fast acquisition of fluorescence decay profiles in multiple …
Endoscopic Fluorescence Lifetime Imaging for In Vivo Intraoperative Diagnosis of Oral Carcinoma
Y Sun, JE Phipps, J Meier, N Hatami… - Microscopy and …, 2013 - academic.oup.com
A clinically compatible fluorescence lifetime imaging microscopy (FLIM) system was
developed. The system was applied to intraoperative in vivo imaging of head and neck …
developed. The system was applied to intraoperative in vivo imaging of head and neck …