One of the most common brain tumors in children and adults is glioma or astrocytoma. There
are few effective therapies for these cancers, and patients with malignant glioma fare poorly …

One of the most striking hallmarks shared by various neurodegenerative diseases, including
Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis, is microglia …

Tumor-associated macrophages (TAMs) constitute up to 50% of tumor bulk in glioblastoma
(GBM) and play an important role in tumor maintenance and progression. The recently …

Microglia are the resident immune cells of the central nervous system (CNS) that have
distinct ontogeny from other tissue macrophages and play a pivotal role in health and …

For decades, it has been known that the tumor microenvironment is significant for glioma
progression, namely the infiltration of myeloid cells like microglia and macrophages. Hence …

Gliomas are highly dynamic and heterogeneous tumours of the central nervous system
(CNS). They constitute the most common neoplasm of the CNS and the second most …

Microglia and monocytes play a critical role in immune responses to cerebral ischemia.
Previous studies have demonstrated that interferon regulatory factor 4 (IRF4) and IRF5 direct …

Substantial evidence suggests a role for immunotherapy in treating Alzheimer's disease
(AD). While the precise pathophysiology of AD is incompletely understood, clinical trials of …

Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor with a malignant
prognosis. GBM is characterized by high cellular heterogeneity and its progression relies on …

Simple Summary Glioblastoma (GBM) is one of the greatest challenges facing neuro-
oncology today. Current treatments are far from satisfactory and, given the poor prognosis of …