Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of
biliary tract differentiation. CCA is the second most common primary liver tumour and the …

Cholangiocarcinoma constitutes a heterogeneous group of malignancies that can emerge at
any point of the biliary tree. Cholangiocarcinoma is classified into intrahepatic, perihilar and …

The liver is a central organ for homeostasis with unique regenerative capacities. Mature
hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to …

The transcription factor Sox9 was first discovered in patients with campomelic dysplasia, a
haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 …

Cholangiocarcinoma, the second most common hepatobiliary malignancy after
hepatocellular carcinoma, is a heterogeneous disease entity with widely varying radiologic …

Cholangiocytes (ie, the epithelial cells that line the bile ducts) are an important subset of
liver cells. They are actively involved in the modification of bile volume and composition, are …

Liver regeneration is perhaps the most studied example of compensatory growth aimed to
replace loss of tissue in an organ. Hepatocytes, the main functional cells of the liver, manage …

Intrahepatic cholangiocarcinomas (ICC s) are made up of heterogenous carcinomas arising
from different anatomical sites of the liver. Two types of candidate stem/progenitor cells of …

Peribiliary glands (PBG) are a source of stem/progenitor cells organized in a cellular
network encircling large bile ducts. Severe cholangiopathy with loss of luminal biliary …

Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of
biliary tract differentiation. CCA is the second most common primary liver tumour and the …