Bone undergoes continuous remodeling, which is homeostatically regulated by concerted
communication between bone-forming osteoblasts and bone-degrading osteoclasts …

Receptor-mediated endocytosis provides a mechanism for the selective uptake of specific
molecules thereby controlling the composition of the extracellular environment and …

Women experience osteoporosis at higher rates than men. Aside from hormones, the
mechanisms driving sex-dependent bone mass regulation are not well understood. Here …

The pace of repair declines with age and, while exposure to a young circulation can
rejuvenate fracture repair, the cell types and factors responsible for rejuvenation are …

Osteoporosis affects millions worldwide and is often caused by osteoclast induced bone
loss. Here, we identify the cytoplasmic protein ELMO1 as an important 'signaling node'in …

Ellagic acid (EA) is a naturally occurring polyphenolic compound that has been shown to
exhibit diverse beneficial pharmacological activities including anti-osteoclastogenesis effect …

Bone-resorbing osteoclasts mobilize proteolytic enzymes belonging to the matrix
metalloproteinase (MMP) family to directly degrade type I collagen, the dominant …

Abstract Ethnopharmacological relevance QingYan Formula has been traditionally used to
tonify kidney and benefit essence, and QingYan Formula 70% ethanol extracts (QYFE) …

Forsythiaside A, a major bioactive component extracted from Forsythiae fructus, possesses
multiple biological properties, especially anti-inflammatory properties. In the present study …

Abstract Objective Leptin receptor-positive (LepR+) periodontal ligament (PDL) cells play a
crucial role in osteogenesis during tooth socket healing and orthodontic tooth movement; …