Alterations in the gut microbiota composition have been associated with a range of
neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The gut microbes …

Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions,
including ATP production, oxidative stress management, and synthesis of neurotransmitters …

The precursor cells for metabolically beneficial beige adipocytes can alternatively become
fibrogenic and contribute to adipose fibrosis. We found that cold exposure or β3-adrenergic …

Although the mechanisms underlying the anti-seizure effects of the high-fat ketogenic diet
(KD) remain unclear, a long-standing question has been whether ketone bodies (ie, β …

The cellular, molecular, and metabolic mechanisms that underlie the development of mesial
temporal lobe epilepsy are incompletely understood. Here we review the role of astrocytes …

The ketogenic diet (KD) is a high-fat, low-carbohydrate treatment for medically intractable
epilepsy. One of the hallmark features of the KD is the production of ketone bodies which …

There is growing evidence that ketone bodies (KB)—derived from fatty acid oxidation and
produced during fasting or consumption of high-fat diets—can exert broad neuroprotective …

A ketogenic diet (KD) is a normocaloric diet composed by high fat (80–90%), low
carbohydrate, and low protein consumption that induces fasting-like effects. KD increases …

Emerging evidence indicates the role of amino acid metabolism in sleep regulation. Here we
demonstrate sleep-promoting effects of dietary threonine (SPET) in Drosophila. Dietary …

Current anti-seizure drugs (ASDs) are believed to reduce neuronal excitability through
modulation of ion channels and transporters that regulate excitability at the synaptic level …