Two coding variants of apolipoprotein L1 (APOL1), called G1 and G2, explain much of the
excess risk of kidney disease in African Americans. While various cytotoxic phenotypes have …

Transplantation remains the gold‐standard treatment for pediatric end‐stage kidney
disease. While living donor transplant is the preferred option for most pediatric patients, it is …

Glomerular diseases are classified using a descriptive taxonomy that is not reflective of the
heterogeneous underlying molecular drivers. This limits not only diagnostic and therapeutic …

Notwithstanding remaining controversies and uncertainties, promising genomically precise
therapies targeted at APOL1 mRNA using antisense oligonucleotides (ASO), inhibitors of …

Focal segmental glomerulosclerosis (FSGS), a pattern of injury seen in some patients with
nephrotic syndrome, is a leading cause of chronic kidney disease (CKD), especially in …

APOL1-mediated kidney diseases have forever changed nephrology and kidney
transplantation. Neves et al. extend this field with analyses in admixed Brazilians with the …

Apolipoprotein L1 (APOL1) nephropathy results from several podocyte dysfunctions
involving morphological and motility changes, mitochondrial perturbations, inflammatory …

ABSTRACT Introduction Individuals of recent West African ancestry develop focal segmental
glomerulosclerosis (FSGS) and hypertension-attributed end stage kidney disease (HTN …

Introduction SARS-CoV-2 infection increases systemic inflammatory cytokines which act as
a second-hit driver of APOL1-mediated collapsing glomerulopathy. SARS-CoV-2 …

Background APOL1 variants G1 and G2 are common in populations with recent sub-
Saharan African ancestry. They are known to influence health conditions: most notably …