Glioblastoma (GB) is the most common subtype of primary brain tumor in adults. These
tumors are highly invasive, very aggressive, and often infiltrate critical neurological areas …

Due to lack of effective therapy, primary brain tumors are the focus of intense investigation of
novel experimental approaches that use vectors and recombinant viruses. Therapeutic …

Abstract Interleukin 17 (IL-17) is a proinflammatory cytokine produced by activated CD4+
memory T cells. We previously showed that IL-17 increased the growth rate of human …

This report describes a test of the hypothesis that the oncolytic effect of genetically
engineered, replication competent herpes simplex viruses (HSV) depends both on cell …

The role of Th2 cells and the cytokines produced by these cells on experimental pulmonary
metastasis of B16 melanoma was investigated in a murine model implanted with high …

OBJECTIVE: Despite advances in conventional therapy, the prognosis for most glioma
patients remains dismal. This has prompted an intensive search for effective treatment …

Galactose was introduced to poly (l-lysine)(PLL) with an average molecular weight of 13,000
to develop a hepatocyte-specific carrier for gene drugs. The pharmacokinetic characteristics …

Preclinical studies with recombinant murine interleukin 4 (IL4) in models of cancer have
shown potent tumor growth inhibition. However, systemic administration of human IL4 to …

Glioblastoma multiforme (GBM) is the most frequent and devastating primary brain tumor in
adults. Despite current treatment modalities, such as surgical resection followed by …

Gene expression was assessed in three types of mouse solid tumors after direct injection of
naked plasmid DNA encoding the luciferase gene (pCMV-Luc) and its DC-chol liposome …