This paper is the third in a series of reviews published in this issue resulting from the
University of California Davis Cardiovascular Symposium 2014: Systems approach to …

Ischemic heart disease is the most common cause of lethal ventricular arrhythmias and
sudden cardiac death (SCD). In patients who are at high risk after myocardial infarction …

Cx43, a major cardiac connexin, forms precursor hemichannels that accrue at the
intercalated disc to assemble as gap junctions. While gap junctions are crucial for electrical …

NCX proteins explore the electrochemical gradient of Na+ to mediate Ca 2+-fluxes in
exchange with Na+ either in the Ca 2+-efflux (forward) or Ca 2+-influx (reverse) mode …

Improved treatments for heart failure patients will require the development of novel
therapeutic strategies that target basal disease mechanisms. Disrupted cardiomyocyte Ca2+ …

Chronic heart failure is a clinical syndrome with multiple etiologies, associated with
significant morbidity and mortality. Cardiac arrhythmias, including ventricular …

It has been documented that Ca 2+ overload and increased production of reactive oxygen
species play a significant role in reperfusion injury (RI) of cardiomyocytes …

Heart failure (HF) is associated with elevated sympathetic tone and mechanical load. Both
systems activate signaling transduction pathways that increase cardiac output, but …

Abstract Intracellular calcium (Ca2+) cycling is tightly regulated in the healthy heart ensuring
effective contraction. This is achieved by transverse (t)‐tubule membrane invaginations that …

Background In this study the effects of a new, highly selective sodium-calcium exchanger
(NCX) inhibitor, ORM-10962 were investigated on cardiac NCX current, Ca2+ transients, cell …