The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …

Genome-wide discovery efforts have identified more than 500 genetic loci associated with
adiposity traits. The vast majority of these loci were found through large-scale meta-analyses …

Background The incidence of type 1 diabetes (T1D) is increasing globally. One hypothesis is
that increasing childhood obesity rates may explain part of this increase, but, as T1D is rare …

Obesity is a common complex trait that elevates the risk for various diseases, including type
2 diabetes and cardiovascular disease. A combination of environmental and genetic factors …

TMEM18 is the strongest candidate for childhood obesity identified from GWASs, yet as for
most GWAS-derived obesity-susceptibility genes, the functional mechanism remains elusive …

Various studies showed that a “one size fits all” dietary recommendation for weight
management is questionable. For this reason, the focus increasingly falls on personalised …

Objective This study aimed to explore shared genetic etiology and the causality between
smoking status and type 2 diabetes (T2D), cardiovascular diseases (CVDs), and related …

The stability of endosymbiotic associations between eukaryotes and bacteria depends on a
reliable mechanism ensuring vertical inheritance of the latter. Here, we demonstrate that a …

Background Several obesity susceptibility loci in genes, including GNPDA2, SH2B1,
TMEM18, MTCH2, CDKAL1, FAIM2, and MC4R, have been identified by genome-wide …

Simple Summary Understanding the evolutionary association between immune cells and
the blood–brain barrier (BBB) is vital to develop therapeutic approaches. In Drosophila, glial …