The pathophysiology and consequences of red blood cell storage

D Orlov, K Karkouti - Anaesthesia, 2015 - Wiley Online Library
Red cell transfusion therapy is a common treatment modality in contemporary medical
practice. Although blood collection and administration is safer and more efficient than ever …

[HTML][HTML] The involvement of cation leaks in the storage lesion of red blood cells

JF Flatt, WM Bawazir, LJ Bruce - Frontiers in physiology, 2014 - frontiersin.org
Stored blood components are a critical life-saving tool provided to patients by health
services worldwide. Red cells may be stored for up to 42 days, allowing for efficient blood …

Absence of neocytolysis in humans returning from a 3‐week high‐altitude sojourn

M Klein, L Kaestner, AY Bogdanova, G Minetti… - Acta …, 2021 - Wiley Online Library
Aims Total haemoglobin mass (tot‐Hb) increases during high‐altitude acclimatization.
Normalization of tot‐Hb upon descent is thought to occur via neocytolysis, the selective …

[HTML][HTML] Phosphatidylserine exposure in human red blood cells depending on cell age

MC Wesseling, L Wagner-Britz, H Huppert… - Cellular physiology and …, 2016 - karger.com
Background/Aims: The exposure of phosphatidylserine (PS) on the outer membrane leaflet
of red blood cells (RBCs) serves as a signal for suicidal erythrocyte death or eryptosis, which …

[HTML][HTML] Survival of red blood cells after transfusion: processes and consequences

GJ Bosman - Frontiers in physiology, 2013 - frontiersin.org
The currently available data suggest that efforts toward improving the quality of red blood
cell (RBC) blood bank products should concentrate on:(1) preventing the removal of a …

Red blood cell senescence and neocytolysis in humans after high altitude acclimatization

A Risso, M Turello, F Biffoni, G Antonutto - Blood Cells, Molecules, and …, 2007 - Elsevier
A selective lysis of relatively young erythrocytes (neocytolysis), together with a decrease of
erythropoietin (EPO) production, has been described in polycythemic, high altitude …

[HTML][HTML] Red cell investigations: art and artefacts

G Minetti, S Egée, D Mörsdorf, P Steffen, A Makhro… - Blood reviews, 2013 - Elsevier
Red blood cell research is important for both, the clinical haematology, such as transfusion
medicine or anaemia investigations, and the basic research fields like exploring general …

[HTML][HTML] Individual osmotic fragility distribution: a new parameter for determination of the osmotic properties of human red blood cells

T Walski, L Chludzińska, M Komorowska… - BioMed Research …, 2014 - hindawi.com
The aim of our experiments was to characterise and to validate the osmotic fragility test
when applied to human blood samples with no significant alterations of osmotic fragility but …

[HTML][HTML] Neocytolysis: none, one or many? A reappraisal and future perspectives

A Risso, A Ciana, C Achilli, G Antonutto… - Frontiers in …, 2014 - frontiersin.org
Neocytolysis is the hypothesis formulated to explain experimental evidence of selective lysis
of young red blood cells (RBCs)(neocytes) associated with decreased plasma levels of …

[HTML][HTML] Red blood cell subpopulations in freshly drawn blood: application of proteomics and metabolomics to a decades-long biological issue

A D'Alessandro, B Blasi, GM D'Amici… - Blood …, 2013 - ncbi.nlm.nih.gov
Background It has long been known that red blood cells comprise various subpopulations,
which can be separated through Percoll density gradients. Materials and methods In this …