Innate metabolic responses against viral infections

CS Palmer - Nature Metabolism, 2022 - nature.com
Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …

Effects of boosting and waning in highly exposed populations on dengue epidemic dynamics

RA Aogo, JV Zambrana, N Sanchez, S Ojeda… - Science translational …, 2023 - science.org
Sequential infection with multiple dengue virus (DENV) serotypes is thought to induce
enduring protection against dengue disease. However, long-term antibody waning has been …

Obesity dysregulates the pulmonary antiviral immune response

M Almond, HA Farne, MM Jackson, A Jha… - Nature …, 2023 - nature.com
Obesity is a well-recognized risk factor for severe influenza infections but the mechanisms
underlying susceptibility are poorly understood. Here, we identify that obese individuals …

The spectrum of influenza in children

G Hoy, G Kuan, R López, N Sánchez… - Clinical Infectious …, 2023 - academic.oup.com
Background Children constitute an important component of the influenza burden and
community transmission, but the frequency of asymptomatic infection and post-influenza …

Angiotensin‐converting enzyme 2: a protective factor in regulating disease virulence of SARS‐COV‐2

V Mariappan, A Balakrishna Pillai - IUBMB life, 2020 - Wiley Online Library
Novel SARS‐CoV‐2 named due to its close homology with severe acute respiratory
syndrome coronavirus (SARS‐CoV) is the etiologic agent for the ongoing pandemic …

Increased population susceptibility to seasonal influenza during the COVID‐19 pandemic in China and the United States

Q Wang, M Jia, M Jiang, Y Cao, P Dai… - Journal of Medical …, 2023 - Wiley Online Library
To the best of our knowledge, no previous study has quantitatively estimated the dynamics
and cumulative susceptibility to influenza infections after the widespread lifting of COVID‐19 …

Diet-induced obesity affects influenza disease severity and transmission dynamics in ferrets

V Meliopoulos, R Honce, B Livingston, V Hargest… - Science …, 2024 - science.org
Obesity, and the associated metabolic syndrome, is a risk factor for increased disease
severity with a variety of infectious agents, including influenza virus. Yet, the mechanisms …

[HTML][HTML] Multifaceted metabolic role of infections in the tumor microenvironment

HF Willenbockel, B Dowerg, T Cordes - Current Opinion in Biotechnology, 2024 - Elsevier
HighlightsBacteria and viruses alter the TME pro-or anti-tumorigenic.Metabolic changes in
the TME affect tumor proliferation and metastasis.Engineered bacteria and viruses are …

Elevated body mass index is not significantly associated with reduced influenza vaccine effectiveness

JP King, HQ Nguyen, EL Kiniry, CH Phillips… - Scientific Reports, 2024 - nature.com
Elevated body mass index (BMI) has been linked to severe influenza illness and impaired
vaccine immunogenicity, but the relationship between BMI and clinical vaccine effectiveness …

Obesity in adolescents does not influence early immune responses to influenza vaccination

I Kristinsdottir, A Haraldsson, SF Brynjolfsson… - Infectious …, 2023 - Taylor & Francis
Background Obesity has been linked to reduced vaccine responses against tetanus,
hepatitis B and influenza. Data on the influence of paediatric obesity on influenza vaccine …