Binding mechanisms in supramolecular complexes

HJ Schneider - Angewandte Chemie International Edition, 2009 - Wiley Online Library
Forces to reckon with: Supramolecular complexes, such as the one shown, are normally
based on a combination of different interactions such as ion pairing, hydrogen bonds, and …

Protein–excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development

TJ Kamerzell, R Esfandiary, SB Joshi… - Advanced drug delivery …, 2011 - Elsevier
The purpose of this review is to demonstrate the critical importance of understanding protein–
excipient interactions as a key step in the rational design of formulations to stabilize and …

The CH/π hydrogen bond in chemistry. Conformation, supramolecules, optical resolution and interactions involving carbohydrates

M Nishio - Physical Chemistry Chemical Physics, 2011 - pubs.rsc.org
The CH/π hydrogen bond is an attractive molecular force occurring between a soft acid and
a soft base. Contribution from the dispersion energy is important in typical cases where …

CH–π hydrogen bonds in biological macromolecules

M Nishio, Y Umezawa, J Fantini, MS Weiss… - Physical Chemistry …, 2014 - pubs.rsc.org
This is a sequel to the previous Perspective “The CH–π hydrogen bond in chemistry.
Conformation, supramolecules, optical resolution and interactions involving carbohydrates” …

Relevance of weak hydrogen bonds in the conformation of organic compounds and bioconjugates: evidence from recent experimental data and high-level ab initio …

O Takahashi, Y Kohno, M Nishio - Chemical reviews, 2010 - ACS Publications
Organic chemists tend to consider the conformation of compounds as a consequence of
repulsive steric interactions. In other words,“the steric effect” means “repulsive” in many …

CH/π hydrogen bonds in organic and organometallic chemistry

M Nishio, Y Umezawa, K Honda, S Tsuboyama… - …, 2009 - pubs.rsc.org
This treatise is an update to a preceding highlight (CH/π hydrogen bonds in crystals)
published in this journal 5 years ago (M. Nishio, CrystEngComm, 2004, 6, 130–156). After …

Galectins as molecular targets for therapeutic intervention

RPM Dings, MC Miller, RJ Griffin, KH Mayo - International journal of …, 2018 - mdpi.com
Galectins are a family of small, highly conserved, molecular effectors that mediate various
biological processes, including chemotaxis and angiogenesis, and that function by …

CH/π interactions in carbohydrate recognition

V Spiwok - Molecules, 2017 - mdpi.com
Many carbohydrate-binding proteins contain aromatic amino acid residues in their binding
sites. These residues interact with carbohydrates in a stacking geometry via CH/π …

Extended weak bonding interactions in DNA: π-stacking (base− base), base− backbone, and backbone− backbone interactions

CF Matta, N Castillo, RJ Boyd - The Journal of Physical Chemistry …, 2006 - ACS Publications
We report on several weak interactions in nucleic acids, which, collectively, can make a
nonnegligible contribution to the structure and stability of these molecules. Fragments of …

DNA–protein π-interactions in nature: abundance, structure, composition and strength of contacts between aromatic amino acids and DNA nucleobases or …

KA Wilson, JL Kellie, SD Wetmore - Nucleic acids research, 2014 - academic.oup.com
Four hundred twenty-eight high-resolution DNA–protein complexes were chosen for a
bioinformatics study. Although 164 crystal structures (38% of those searched) contained no …