Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

The coagulase-negative bacterium Staphylococcus epidermidis is a member of the human
skin microbiota. S. epidermidis is not merely a passive resident on skin but actively primes …

The microbiomes on human body surfaces affect health in multiple ways. They include not
only commensal or mutualistic bacteria but also potentially pathogenic bacteria, which can …

Acne is a highly prevalent inflammatory skin condition involving sebaceous sties. Although it
clearly develops from an interplay of multiple factors, the exact cause of acne remains …

Lanthipeptides are ribosomally synthesized and post-translationally modified peptides
(RiPPs) that display a wide variety of biological activities, from antimicrobial to antiallodynic …

BACKGROUND Two developments in distinct fields are converging to create interest in
discovering small molecules from the human microbiome. First, the use of genomics to guide …

Coagulase-negative staphylococci (CoNS) have emerged as major pathogens in healthcare-
associated facilities, being S. epidermidis, S. haemolyticus and, more recently, S …

Staphylococcus epidermidis is a permanent member of the normal human microbiota,
commonly found on skin and mucous membranes. By adhering to tissue surface moieties of …

Microbes found on the skin are usually regarded as pathogens, potential pathogens or
innocuous symbiotic organisms. Advances in microbiology and immunology are revising our …

Lipid II is a membrane-anchored cell-wall precursor that is essential for bacterial cell-wall
biosynthesis. The effectiveness of targeting Lipid II as an antibacterial strategy is highlighted …