A sustainable synthesis of green carbon quantum dot (CQD) from Catharanthus roseus (white flowering plant) leaves and investigation of its dual fluorescence …
T Arumugham, M Alagumuthu, RG Amimodu… - Sustainable Materials …, 2020 - Elsevier
In this work, we have presented a facile, efficient and green strategy to prepare fluorescence
CQD for multi ion sensing and bio imaging application. Hydrothermal carbonization …
CQD for multi ion sensing and bio imaging application. Hydrothermal carbonization …
Piperazine-azole-fluoroquinolone hybrids: Conventional and microwave irradiated synthesis, biological activity screening and molecular docking studies
Abstract A series of new 1, 2, 4-triazole and 1, 3, 4-oxadiazole derivatives was obtained via
several steps sequential reactions of phenyl piperazine. Then, these compounds were …
several steps sequential reactions of phenyl piperazine. Then, these compounds were …
[HTML][HTML] In Silico Approach of Potential Phytochemical Inhibitor from Moringa oleifera, Cocos nucifera, Allium cepa, Psidium guajava, and Eucalyptus globulus for the …
Background: Coronavirus disease 2019 (COVID-19) is caused by infection with severe
acute respiratory syndrome coronavirus 2. COVID-19 has devastating effects on people in …
acute respiratory syndrome coronavirus 2. COVID-19 has devastating effects on people in …
Drug repurposing of novel quinoline acetohydrazide derivatives as potent COX-2 inhibitors and anti-cancer agents
CS Manohar, A Manikandan, P Sridhar… - Journal of Molecular …, 2018 - Elsevier
Abstract Novel QuinolineAcetohydrazide (QAh) derivatives (9a-n) were firstly evaluated in
silico to determine their anti-inflammatory and anti-cancer efficacy via the mechanisms of …
silico to determine their anti-inflammatory and anti-cancer efficacy via the mechanisms of …
Computational approaches to develop isoquinoline based antibiotics through DNA gyrase inhibition mechanisms unveiled through antibacterial evaluation and …
M Alagumuthu, VP Muralidharan, M Andrew… - Molecular …, 2018 - Wiley Online Library
Developing a new antibacterial drug by using (Z/E)‐4‐(4‐substituted‐benzylidene)‐2‐
isoquinoline‐1, 3 (2H, 4H)‐diones (5a–h) via DNA gyrase inhibition mechanism is the main …
isoquinoline‐1, 3 (2H, 4H)‐diones (5a–h) via DNA gyrase inhibition mechanism is the main …
Therapeutic investigations of novel indoxyl-based indolines: A drug target validation and Structure-Activity Relationship of angiotensin-converting enzyme inhibitors …
A family of 12 members of Naphthalene-2-ol-indolin-2-one-thiocarbamides (5a-l) with
pharmacological potentials of cardiovascular modulator were efficiently synthesized and …
pharmacological potentials of cardiovascular modulator were efficiently synthesized and …
Synthesis, biological activity and structure activity relationship studies of novel conazole analogues via conventional, microwave and ultrasound mediated techniques
Triazole derivatives containing a piperazine nucleus (4a-d and 10) were prepared starting
from 1-(2-methoxyphenyl) piperazine or ethyl 4-(4-amino-2-fluorophenyl) piperazine-1 …
from 1-(2-methoxyphenyl) piperazine or ethyl 4-(4-amino-2-fluorophenyl) piperazine-1 …
An eco-friendly catalytic system for multicomponent, one-pot synthesis of novel spiro-chromeno indoline-triones and their anti-prostate cancer potentials evaluated via …
MR Kumar, A Manikandan, A Sivakumar… - Bioorganic …, 2018 - Elsevier
A green and efficient straightforward tactic for the one-pot regioselective synthesis of novel
10, 10-dimethyl-9, 10, 11, 11a-tetrahydro-6H-spiro [chromeno [4, 3–b] chromene-7, 3 …
10, 10-dimethyl-9, 10, 11, 11a-tetrahydro-6H-spiro [chromeno [4, 3–b] chromene-7, 3 …
Unveiling novel 2-cyclopropyl-3-ethynyl-4-(4-fluorophenyl) quinolines as GPCR ligands via PI3-kinase/PAR-1 antagonism and platelet aggregation valuations; …
P Thangarasu, ST Selvi, A Manikandan - Bioorganic Chemistry, 2018 - Elsevier
In the present study, novel 2-cyclopropyl-3-ethynyl-4-(4-fluorophenyl) quinolines (4a-l) were
recognized and evaluated as G-Protein Coupled Receptor (GPCR) ligands through …
recognized and evaluated as G-Protein Coupled Receptor (GPCR) ligands through …
Discovery, synthesis and molecular corroborations of medicinally important novel pyrazoles; drug efficacy determinations through in silico, in vitro and cytotoxicity …
P Thangarasu, A Manikandan, S Thamaraiselvi - Bioorganic Chemistry, 2019 - Elsevier
As the global need for drugs getting increases, the necessity of novel and effective drugs are
the need of the day. Pyrazoles are one of the active molecules in novel drug discovery. The …
the need of the day. Pyrazoles are one of the active molecules in novel drug discovery. The …