The accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER
stress, resulting in activation of the unfolded protein response (UPR) that aims to restore …

Protein handling, modification and folding in the endoplasmic reticulum (ER) are tightly
regulated processes that determine cell function, fate and survival. In several tumour types …

Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …

To survive, cancer cells must resist numerous internal and environmental insults associated
with neoplasia that jeopardize proteostasis within the endoplasmic reticulum (ER). Solid and …

The Myc proto-oncogene family consists of three members, C-MYC, MYCN, and MYCL,
which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and L-Myc …

The acquisition of genetic alterations, clonal evolution, and the tumor microenvironment
promote cancer progression, metastasis and therapy resistance. These events correspond …

Initiating and maintaining optimal immune responses requires high levels of protein
synthesis, folding, modification and trafficking in leukocytes, which are processes …

A hostile microenvironment in tumor tissues disrupts endoplasmic reticulum homeostasis
and induces the unfolded protein response (UPR). A chronic UPR in both cancer cells and …

Accumulation of unfolded proteins at the endoplasmic reticulum (ER) is a salient attribute of
many human diseases including obesity, liver disorders, cancer, diabetes and …

The life expectancy of the global population has increased. Aging is a natural physiological
process that poses major challenges in an increasingly long-lived and frail population …