Comparative cellular analysis of motor cortex in human, marmoset and mouse

TE Bakken, NL Jorstad, Q Hu, BB Lake, W Tian… - Nature, 2021 - nature.com
The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals. Here, using high-throughput transcriptomic and epigenomic …

Human neocortical expansion involves glutamatergic neuron diversification

J Berg, SA Sorensen, JT Ting, JA Miller, T Chartrand… - Nature, 2021 - nature.com
The neocortex is disproportionately expanded in human compared with mouse,, both in its
total volume relative to subcortical structures and in the proportion occupied by …

[HTML][HTML] Neuronal types in the mouse amygdala and their transcriptional response to fear conditioning

H Hochgerner, S Singh, M Tibi, Z Lin… - Nature …, 2023 - nature.com
The amygdala is a brain region primarily associated with emotional response. The use of
genetic markers and single-cell transcriptomics can provide insights into behavior …

Pathophysiology and treatment of memory dysfunction after traumatic brain injury

R Paterno, KA Folweiler, AS Cohen - Current neurology and neuroscience …, 2017 - Springer
Memory is fundamental to everyday life, and cognitive impairments resulting from traumatic
brain injury (TBI) have devastating effects on TBI survivors. A contributing component to …

Dendritic action potentials and computation in human layer 2/3 cortical neurons

A Gidon, TA Zolnik, P Fidzinski, F Bolduan, A Papoutsi… - Science, 2020 - science.org
The active electrical properties of dendrites shape neuronal input and output and are
fundamental to brain function. However, our knowledge of active dendrites has been almost …

[HTML][HTML] Shared and distinct transcriptomic cell types across neocortical areas

B Tasic, Z Yao, LT Graybuck, KA Smith, TN Nguyen… - Nature, 2018 - nature.com
The neocortex contains a multitude of cell types that are segregated into layers and
functionally distinct areas. To investigate the diversity of cell types across the mouse …

Cerebellar modulation of the reward circuitry and social behavior

I Carta, CH Chen, AL Schott, S Dorizan, K Khodakhah - Science, 2019 - science.org
INTRODUCTION Although the cerebellum has long been considered to be a purely motor
structure, recent studies have revealed that it also has critical nonmotor functions. Cerebellar …

Molecularly targetable cell types in mouse visual cortex have distinguishable prediction error responses

SM O'Toole, HK Oyibo, GB Keller - Neuron, 2023 - cell.com
Predictive processing postulates the existence of prediction error neurons in cortex. Neurons
with both negative and positive prediction error response properties have been identified in …

A suite of transgenic driver and reporter mouse lines with enhanced brain-cell-type targeting and functionality

TL Daigle, L Madisen, TA Hage, MT Valley, U Knoblich… - Cell, 2018 - cell.com
Modern genetic approaches are powerful in providing access to diverse cell types in the
brain and facilitating the study of their function. Here, we report a large set of driver and …

Advances in the automation of whole-cell patch clamp technology

HJ Suk, ES Boyden, I van Welie - Journal of neuroscience methods, 2019 - Elsevier
Electrophysiology is the study of neural activity in the form of local field potentials, current
flow through ion channels, calcium spikes, back propagating action potentials and somatic …