The expression of MHC class I molecules is crucial for the initiation and regulation of
adaptive immune responses against pathogens. NOD-, LRR-and CARD-containing 5 …

The bare lymphocyte syndrome (BLS) is a hereditary immunodeficiency resulting from the
absence of major istocompatibility complex class II (MHCII) expression. Considering the …

MHC class I plays a critical role in the immune defense against viruses and tumors by
presenting antigens to CD8 T cells. An NLR protein, class II transactivator (CIITA), is a key …

By virtue of its control over major histocompatibility complex class II (MHC-II) gene
expression, CIITA represents a key molecule in the regulation of adaptive immune …

Epigenetic mechanisms are involved in regulating chromatin structure and gene expression
through repression. In this study, we show that histone deacetylase inhibitors (DAIs) that …

▪ Abstract The newly discovered CATERPILLER (CLR) gene family encodes proteins with a
variable but limited number of N-terminal domains, followed by a nucleotide-binding domain …

The newly described CATERPILLER family (also known as NOD-LRR or NACHT-LRR) is
comprised of proteins with a nucleotide-binding domain and a leucine-rich region. This …

Mycobacterium tuberculosis (MTB) persists inside macrophages despite vigorous immune
responses. MTB and MTB 19-kDa lipoprotein inhibit class II MHC (MHC-II) expression and …

Major histocompatibility complex (MHC) class II molecules are the predominant presenters
of exogenous antigens to T helper cells (reviewed in references 21, 77, and 99). These key …

Alzheimer's disease (AD) is a progressive dementing neurologic illness, and the most
frequent cause of dementia in the elderly. Neuritic plaques are one of the main …