NLRC5: a key regulator of MHC class I-dependent immune responses
KS Kobayashi, PJ Van Den Elsen - Nature Reviews Immunology, 2012 - nature.com
The expression of MHC class I molecules is crucial for the initiation and regulation of
adaptive immune responses against pathogens. NOD-, LRR-and CARD-containing 5 …
adaptive immune responses against pathogens. NOD-, LRR-and CARD-containing 5 …
The bare lymphocyte syndrome and the regulation of MHC expression
W Reith, B Mach - Annual review of immunology, 2001 - annualreviews.org
The bare lymphocyte syndrome (BLS) is a hereditary immunodeficiency resulting from the
absence of major istocompatibility complex class II (MHCII) expression. Considering the …
absence of major istocompatibility complex class II (MHCII) expression. Considering the …
NLR family member NLRC5 is a transcriptional regulator of MHC class I genes
TB Meissner, A Li, A Biswas, KH Lee… - Proceedings of the …, 2010 - National Acad Sciences
MHC class I plays a critical role in the immune defense against viruses and tumors by
presenting antigens to CD8 T cells. An NLR protein, class II transactivator (CIITA), is a key …
presenting antigens to CD8 T cells. An NLR protein, class II transactivator (CIITA), is a key …
CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex
K Masternak, A Muhlethaler-Mottet… - Genes & …, 2000 - genesdev.cshlp.org
By virtue of its control over major histocompatibility complex class II (MHC-II) gene
expression, CIITA represents a key molecule in the regulation of adaptive immune …
expression, CIITA represents a key molecule in the regulation of adaptive immune …
Activation of MHC class I, II, and CD40 gene expression by histone deacetylase inhibitors
WJ Magner, AL Kazim, C Stewart… - The Journal of …, 2000 - journals.aai.org
Epigenetic mechanisms are involved in regulating chromatin structure and gene expression
through repression. In this study, we show that histone deacetylase inhibitors (DAIs) that …
through repression. In this study, we show that histone deacetylase inhibitors (DAIs) that …
CATERPILLER: a novel gene family important in immunity, cell death, and diseases
JPY Ting, BK Davis - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract The newly discovered CATERPILLER (CLR) gene family encodes proteins with a
variable but limited number of N-terminal domains, followed by a nucleotide-binding domain …
variable but limited number of N-terminal domains, followed by a nucleotide-binding domain …
CATERPILLERs, pyrin and hereditary immunological disorders
JPY Ting, DL Kastner, HM Hoffman - Nature Reviews Immunology, 2006 - nature.com
The newly described CATERPILLER family (also known as NOD-LRR or NACHT-LRR) is
comprised of proteins with a nucleotide-binding domain and a leucine-rich region. This …
comprised of proteins with a nucleotide-binding domain and a leucine-rich region. This …
Inhibition of IFN-γ-induced class II transactivator expression by a 19-kDa lipoprotein from Mycobacterium tuberculosis: a potential mechanism for immune evasion
RK Pai, M Convery, TA Hamilton, WH Boom… - The Journal of …, 2003 - journals.aai.org
Mycobacterium tuberculosis (MTB) persists inside macrophages despite vigorous immune
responses. MTB and MTB 19-kDa lipoprotein inhibit class II MHC (MHC-II) expression and …
responses. MTB and MTB 19-kDa lipoprotein inhibit class II MHC (MHC-II) expression and …
Class II transactivator: mastering the art of major histocompatibility complex expression
JA Harton, JPY Ting - Molecular and cellular biology, 2000 - Taylor & Francis
Major histocompatibility complex (MHC) class II molecules are the predominant presenters
of exogenous antigens to T helper cells (reviewed in references 21, 77, and 99). These key …
of exogenous antigens to T helper cells (reviewed in references 21, 77, and 99). These key …
Immunological aspects of microglia: relevance to Alzheimer's disease
EN Benveniste, VT Nguyen, GM O'Keefe - Neurochemistry international, 2001 - Elsevier
Alzheimer's disease (AD) is a progressive dementing neurologic illness, and the most
frequent cause of dementia in the elderly. Neuritic plaques are one of the main …
frequent cause of dementia in the elderly. Neuritic plaques are one of the main …