Current techniques of water solubility improvement for antioxidant compounds and their correlation with its activity: molecular pharmaceutics

A Budiman, A Rusdin, DL Aulifa - Antioxidants, 2023 - mdpi.com
The aqueous solubility of a drug is important in the oral formulation because the drug can be
absorbed from intestinal sites after being dissolved in the gastrointestinal fluid, leading to its …

Folate-engineered chitosan nanoparticles: next-generation anticancer nanocarriers

P Kesharwani, K Halwai, SK Jha, MH Al Mughram… - Molecular Cancer, 2024 - Springer
Chitosan nanoparticles (NPs) are well-recognized as promising vehicles for delivering
anticancer drugs due to their distinctive characteristics. They have the potential to enclose …

Synthesis and characterization of chitosan/carbon quantum dots/Fe2O3 nanocomposite comprising curcumin for targeted drug delivery in breast cancer therapy

M Zoghi, M Pourmadadi, F Yazdian, MN Nigjeh… - International Journal of …, 2023 - Elsevier
Curcumin, a natural compound with promising anti-cancerous features, suffers from a
number of shortcomings such as low chemical stability, bioavailability, and solubility, which …

Inhibition of crystal nucleation and growth in aqueous drug solutions: impact of different polymers on the supersaturation profiles of amorphous drugs—the case of …

A Budiman, ZG Citraloka, M Muchtaridi, S Sriwidodo… - Pharmaceutics, 2022 - mdpi.com
The polymer used in supersaturated solutions plays a critical role in maintaining
supersaturation levels of amorphous drugs. The prevention of drug crystallization in the …

Inhibition of Crystal Nucleation and Growth: A Review

Y Zhang, B Li, J Liu, D Han, S Rohani… - Crystal Growth & …, 2024 - ACS Publications
The formation of crystalline materials typically follows the nucleation and crystal growth
pathway, which enables scientists to engineer crystal properties, and the metastable status …

Advancing drug delivery paradigms: Polyvinyl pyrolidone (PVP)-based amorphous solid dispersion for enhanced physicochemical properties and therapeutic efficacy

A Rusdin, A Mohd Gazzali, N Ain Thomas… - Polymers, 2024 - mdpi.com
Background: The current challenge in drug development lies in addressing the
physicochemical issues that lead to low drug effectiveness. Solubility, a crucial …

Gelatin and chitosan as meat by-products and their recent applications

MA Elgadir, AA Mariod - Foods, 2022 - mdpi.com
Meat by-products such as bones, skin, horns, hooves, feet, skull, etc., are produced from
slaughtered mammals. Innovative solutions are very important to achieving sustainability …

Drug-Coformer Loaded-Mesoporous Silica Nanoparticles: A Review of the Preparation, Characterization, and Mechanism of Drug Release

A Budiman, YW Wardhana, A Ainurofiq… - International Journal …, 2024 - Taylor & Francis
Drug-coformer systems, such as coamorphous and cocrystal, are gaining recognition as
highly effective strategies for enhancing the stability, solubility, and dissolution of drugs …

Characterizing the impact of chitosan on the nucleation and crystal growth of ritonavir from supersaturated solutions

A Budiman, K Kalina, L Aristawidya, AAA Shofwan… - Polymers, 2023 - mdpi.com
The addition of polymeric materials is often used to delay nucleation or crystal growth and
maintain the high supersaturation of amorphous drugs. Therefore, this study aimed to …

Sugars and Polyols of Natural Origin as Carriers for Solubility and Dissolution Enhancement

MS Poka, M Milne, A Wessels, M Aucamp - Pharmaceutics, 2023 - mdpi.com
Crystalline carriers such as dextrose, sucrose, galactose, mannitol, sorbitol, and isomalt
have been reported to increase the solubility, and dissolution rates of poorly soluble drugs …