Current techniques of water solubility improvement for antioxidant compounds and their correlation with its activity: molecular pharmaceutics
The aqueous solubility of a drug is important in the oral formulation because the drug can be
absorbed from intestinal sites after being dissolved in the gastrointestinal fluid, leading to its …
absorbed from intestinal sites after being dissolved in the gastrointestinal fluid, leading to its …
Folate-engineered chitosan nanoparticles: next-generation anticancer nanocarriers
P Kesharwani, K Halwai, SK Jha, MH Al Mughram… - Molecular Cancer, 2024 - Springer
Chitosan nanoparticles (NPs) are well-recognized as promising vehicles for delivering
anticancer drugs due to their distinctive characteristics. They have the potential to enclose …
anticancer drugs due to their distinctive characteristics. They have the potential to enclose …
Synthesis and characterization of chitosan/carbon quantum dots/Fe2O3 nanocomposite comprising curcumin for targeted drug delivery in breast cancer therapy
M Zoghi, M Pourmadadi, F Yazdian, MN Nigjeh… - International Journal of …, 2023 - Elsevier
Curcumin, a natural compound with promising anti-cancerous features, suffers from a
number of shortcomings such as low chemical stability, bioavailability, and solubility, which …
number of shortcomings such as low chemical stability, bioavailability, and solubility, which …
Inhibition of crystal nucleation and growth in aqueous drug solutions: impact of different polymers on the supersaturation profiles of amorphous drugs—the case of …
The polymer used in supersaturated solutions plays a critical role in maintaining
supersaturation levels of amorphous drugs. The prevention of drug crystallization in the …
supersaturation levels of amorphous drugs. The prevention of drug crystallization in the …
Inhibition of Crystal Nucleation and Growth: A Review
Y Zhang, B Li, J Liu, D Han, S Rohani… - Crystal Growth & …, 2024 - ACS Publications
The formation of crystalline materials typically follows the nucleation and crystal growth
pathway, which enables scientists to engineer crystal properties, and the metastable status …
pathway, which enables scientists to engineer crystal properties, and the metastable status …
Advancing drug delivery paradigms: Polyvinyl pyrolidone (PVP)-based amorphous solid dispersion for enhanced physicochemical properties and therapeutic efficacy
A Rusdin, A Mohd Gazzali, N Ain Thomas… - Polymers, 2024 - mdpi.com
Background: The current challenge in drug development lies in addressing the
physicochemical issues that lead to low drug effectiveness. Solubility, a crucial …
physicochemical issues that lead to low drug effectiveness. Solubility, a crucial …
Gelatin and chitosan as meat by-products and their recent applications
MA Elgadir, AA Mariod - Foods, 2022 - mdpi.com
Meat by-products such as bones, skin, horns, hooves, feet, skull, etc., are produced from
slaughtered mammals. Innovative solutions are very important to achieving sustainability …
slaughtered mammals. Innovative solutions are very important to achieving sustainability …
Drug-Coformer Loaded-Mesoporous Silica Nanoparticles: A Review of the Preparation, Characterization, and Mechanism of Drug Release
Drug-coformer systems, such as coamorphous and cocrystal, are gaining recognition as
highly effective strategies for enhancing the stability, solubility, and dissolution of drugs …
highly effective strategies for enhancing the stability, solubility, and dissolution of drugs …
Characterizing the impact of chitosan on the nucleation and crystal growth of ritonavir from supersaturated solutions
A Budiman, K Kalina, L Aristawidya, AAA Shofwan… - Polymers, 2023 - mdpi.com
The addition of polymeric materials is often used to delay nucleation or crystal growth and
maintain the high supersaturation of amorphous drugs. Therefore, this study aimed to …
maintain the high supersaturation of amorphous drugs. Therefore, this study aimed to …
Sugars and Polyols of Natural Origin as Carriers for Solubility and Dissolution Enhancement
Crystalline carriers such as dextrose, sucrose, galactose, mannitol, sorbitol, and isomalt
have been reported to increase the solubility, and dissolution rates of poorly soluble drugs …
have been reported to increase the solubility, and dissolution rates of poorly soluble drugs …