Motions in biomolecules are critical for biochemical reactions. In cells, many biochemical
reactions are executed inside of biomolecular condensates formed by ultradynamic …

In the last two decades, solid-state nuclear magnetic resonance (ssNMR) spectroscopy has
transformed from a spectroscopic technique investigating small molecules and industrial …

Proteins are inherently flexible at ambient temperature. At equilibrium, they are
characterized by a set of conformations that undergo continuous exchange within a …

Revised Manuscript Received March 10, 19949 abstract: The backbone dynamics of the C-
terminal SH2 domain of phospholipase C7I have been investigated. Two forms of the …

Function in biological systems is exquisitely dependent on spatial and temporal changes in
biomacromolecules. Innumerable biological processes ultimately rely on transduction of …

Nuclear magnetic resonance (NMR) is widely used across many fields of science because
of the rich data it produces, and some of the most valuable data come from studies of …

Materials and Methods Sample Preparation. Recombinant Drosophila CaM was prepared
with Escherichia coli (strain AR58) harboring the pAS expression vector (Shatzman & …

Myriad biological processes proceed through states that defy characterization by
conventional atomic-resolution structural biological methods. The invisibility of these …

Ribonuclease H is an endonuclease that hydrolyzes the RNA moiety of RNA–DNA duplex
molecules. Escherichia coliribonuclease H is involved in DNA replication, and retroviral …

Enzyme catalysis is an inherently dynamic process. Binding and release of ligands is often
accompanied by conformational changes, both subtle and dramatic (reviewed more …