After a century of controversy, the notion that the immune system regulates cancer
development is experiencing a new resurgence. An overwhelming amount of data from …

The last fifteen years have seen a reemergence of interest in cancer immunosurveillance
and a broadening of this concept into one termed cancer immunoediting. The latter …

The evolutionary conservation of T lymphocyte subsets bearing T-cell receptors (TCRs)
using invariant α-chains is indicative of unique functions. CD1d-restricted natural killer T (NK …

The human leukocyte antigen (HLA) super-locus is a genomic region in the chromosomal
position 6p21 that encodes the six classical transplantation HLA genes and at least 132 …

The major histocompatibility complex (MHC) is the most important region in the vertebrate
genome with respect to infection and autoimmunity, and is crucial in adaptive and innate …

Natural killer cells are innate immune cells that control certain microbial infections and
tumours. The function of natural killer cells is regulated by a balance between signals …

MICA molecules interact with the NKG2D-activating receptor on human NK and CD8 T cells.
We investigated the participation of the MICA/NKG2D pathway in the destruction of intestinal …

Natural killer cells are important innate immune effector cells with potentially broad
applications in the treatment of human malignancy due to their ability to lyse neoplastic cells …

In 1986, Kärre and colleagues reported that natural killer (NK) cells rejected an MHC class I-
deficient tumor cell line (RMA-S) but they did not reject the same cell line if it expressed …

Natural killer (NK) cells have held great promise for the immunotherapy of cancer for more
than 3 decades. However, to date only modest clinical success has been achieved …