The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …

Since the discovery in 1796 by Edward Jenner of vaccinia virus as a way to prevent and
finally eradicate smallpox, the concept of using a virus to fight another virus has evolved into …

Type I interferon (IFN-α/β) is a fundamental antiviral defense mechanism. Mouse models
have been pivotal to understanding the role of IFN-α/β in immunity, although validation of …

To establish infections in vivo, viruses must replicate in the face of powerful immune defence
mechanisms including those induced by interferons (IFNs). The effectiveness of the IFN …

The lung is highly exposed to the external environment. For this reason, the lung needs to
handle a number of potential threats present in inhaled air such as viruses or bacteria …

West Nile virus (WNV) is a mosquito-borne flavivirus that is neurotropic in humans, birds,
and other animals. While adaptive immunity plays an important role in preventing WNV …

The COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) and has spread worldwide, with millions of cases and more than 1 million …

Clinical immunotherapy approaches are lacking efficacy in the treatment of glioblastoma
(GBM). In this study, we sought to reverse local and systemic GBM-induced …

Attenuated Edmonston lineage measles virus (MV-Edm) vaccine strains can preferentially
infect and lyse a wide variety of cancer cells. Oncolytic MV-Edm derivatives are genetically …

Measles virus (MV), a member of the genus Morbillivirus in the family Paramyxoviridae, is an
enveloped virus with a non-segmented, negative-strand RNA genome. It has two envelope …