BACKGROUND: This systematic review has two purposes: to consolidate the current
knowledge about clinical effectiveness of electrochemotherapy, a highly effective local …

With the recent approval of cladribine tablets, siponimod and ozanimod, there has been a
renewed interest into the extent to which these current generation disease-modifying …

The novel ability to quantify drug and tracer concentrations in vivo by optical means leads to
the possibility of detecting and quantifying blood brain barrier (BBB) disruption in real-time …

Single fiber reflectance spectroscopy is a method to noninvasively quantitate tissue
absorption and scattering properties. This study utilizes a Monte Carlo (MC) model to …

Rapid first pass uptake of drugs is necessary to increase tissue deposition after intraarterial
(IA) injection. Here we tested whether brain tissue deposition of a nanoparticulate liposomal …

BACKGROUND: Optimizing liposomal vehicles for targeted delivery to the brain has
important implications for the treatment of brain tumors. The promise of efficient, brain …

A reflectance spectroscopic device that utilizes a single fiber for both light delivery and
collection has advantages over classical multi-fiber probes. This study presents a novel …

Nanoparticles such as liposomes may be used as drug delivery vehicles for brain tumor
therapy. Particle geometry and electrostatic properties have been hypothesized to be …

The major efforts to selectively deliver drugs to the brain in the past decade have relied on
smart molecular techniques to penetrate the blood-brain barrier, whereas intraarterial drug …

We present an application of spatial frequency-domain imaging (SFDI) to the wide-field
imaging of drug delivery to brain tissue. Measurements were compared with values obtained …