Filamentous fungi produce a number of small bioactive molecules as part of their secondary
metabolism ranging from benign antibiotics such as penicillin to threatening mycotoxins …

A typical protein kinase must recognize between one and a few hundred bona fide
phosphorylation sites in a background of∼ 700,000 potentially phosphorylatable residues …

Methylation of N6-adenosine (m6A) in mRNA is an important posttranscriptional gene
regulatory mechanism in eukaryotes. m6A provides a binding site for effector proteins …

An appropriate response and adaptation to hyperosmolarity, ie., an external osmolarity that
is higher than the physiological range, can be a matter of life or death for all cells. It is …

The ERK signaling cascade is a central MAPK pathway that plays a role in the regulation of
various cellular processes such as proliferation, differentiation, development, learning …

Eukaryotic protein kinases are key regulators of cell processes. Comparison of the structures
of protein kinase domains, both alone and in complexes, allows generalizations to be made …

Mass spectrometry is a powerful technology for the analysis of large numbers of
endogenous proteins,. However, the analytical challenges associated with comprehensive …

Signaling pathways that activate different mitogen-activated protein kinases (MAPKs) elicit
many of the responses that are evoked in cells by changes in certain environmental …

Yeast cells possess a remarkable capacity to adhere to abiotic surfaces, cells and tissues.
These adhesion properties are of medical and industrial relevance. Pathogenic yeasts such …

The mitogen-activated protein (MAP) kinase extracellular-signal-regulated kinases (ERKs)
are activated by diverse mechanisms. These include ligation of receptor tyrosine kinases …