Renal cysts are clinically and genetically heterogeneous conditions. Polycystic kidney
disease (PKD) is common and its characterization has paved the way for the identification of …

Dysfunctional cilia underlie a broad range of cellular and tissue phenotypes and can
eventually result in the development of ciliopathies: pathologically diverse diseases that …

Autosomal dominant polycystic kidney disease (ADPKD) is a progressive inherited disorder
in which renal tissue is gradually replaced with fluid-filled cysts, giving rise to chronic kidney …

Cardiovascular disease (CVD) is the leading cause of premature mortality in ADPKD
patients. The aim was to identify potential serum biomarkers associated with the severity of …

Polycystic kidney disease is characterized by cardiovascular irregularities, including
hypertension. Dopamine, a circulating hormone, is implicated in essential hypertension in …

The primary cilium is an important sensory organelle present in most mammalian cells. Our
current studies aim at examining intracellular molecules that regulate cilia length and/or cilia …

Nephronophthisis-related ciliopathies (NPHP-RCs) are developmental and degenerative
kidney diseases that are frequently associated with extrarenal pathologies such as retinal …

Various cellular insults and injury to renal epithelial cells stimulate repair mechanisms to
adapt and restore the organ homeostasis. Renal tubular epithelial cells are endowed with …

Cilia are antenna-like organelles found on the surface of most cells. They transduce
molecular signals and facilitate interactions between cells and their environment. Ciliary …

The primary cilium protrudes from the cell surface and acts as a sensor for chemical and
mechanical growth cues, with receptors for a number of growth factors (PDGFα, Hedgehog …