Antibacterial and antioxidant activities for natural and synthetic dual-active compounds

G Martelli, D Giacomini - European Journal of Medicinal Chemistry, 2018 - Elsevier
Antimicrobial resistance is widely recognized as a grave threat to global health in the 21st
century, since the past decades have seen a dramatic increase in human-pathogenic …

Past, present and future of xanthine oxidase inhibitors: design strategies, structural and pharmacological insights, patents and clinical trials

A Singh, K Singh, A Sharma, K Kaur… - RSC Medicinal …, 2023 - pubs.rsc.org
Xanthine oxidase, a molybdo-flavoenzyme, and an isoform of xanthine dehydrogenase both
exist as xanthine oxidoreductase and are responsible for purine catabolism. Xanthine …

Antimicrobial and antitumor activity of S-methyl dithiocarbazate Schiff base zinc (II) complexes

F Ramilo-Gomes, Y Addis, I Tekamo, I Cavaco… - Journal of Inorganic …, 2021 - Elsevier
Schiff bases (SB) obtained from S-methyl dithiocarbazate and aromatic aldehydes:
salicylaldehyde (H 2 L 1), o-vanillin (H 2 L 2), pyridoxal (H 2 L 3) and 2, 6-diformyl-4 …

Triple superphosphate modified by tin (II) chloride: As a reusable and efficient catalyst for the one-pot synthesis of xanthene and xanthenone derivatives under green …

Y Merroun, S Chehab, A El Hallaoui, T Guedira… - Journal of Molecular …, 2023 - Elsevier
A simple method was developed for preparing tin (II) chloride-triple superphosphate. The
material was thoroughly characterized using various techniques, including transform …

'Lights, squaraines, action!'–the role of squaraine dyes in photodynamic therapy

E Lima, LV Reis - Future Medicinal Chemistry, 2022 - Taylor & Francis
Since they were first synthesized in 1965 by Treibs and Jacob, squaraine dyes have
revolutionized the polymethine dyes''universe'and their potential applications due to their …

Synthesis and in vitro evaluation of the antitumoral phototherapeutic potential of squaraine cyanine dyes derived from indolenine

E Lima, O Ferreira, VSD Gomes, AO Santos, RE Boto… - Dyes and …, 2019 - Elsevier
In this work several symmetrical indolenine squaraine dyes with different groups positioned
on the four-membered central ring, such as sulfur, barbituric acid, amino and methylamino …

Therapeutic voyage of synthetic and natural xanthine oxidase inhibitors

N Agrawal, M Arya, P Kushwah - Chemical Biology & Drug …, 2023 - Wiley Online Library
Xanthine oxidase (XO) inhibitors are commonly used to treat gout, nephropathy, and renal
stone diseases related to hyperuricemia. However, recent research has shown that these …

Synthetic heterocyclic derivatives as promising xanthine oxidase inhibitors: An overview

G Kaur, A Singh, G Arora, A Monga… - Chemical Biology & …, 2022 - Wiley Online Library
Inhibition of xanthine oxidase (XO) is an effective and most prominent therapeutic approach
for the management of gout. Discovery of its association in the pathophysiology of diabetes …

Novel 3-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-1, 2, 4-oxadiazol-5 (4H)-ones as promising xanthine oxidase inhibitors: Design, synthesis and biological evaluation

J Gao, Z Zhang, B Zhang, Q Mao, X Dai, Q Zou… - Bioorganic …, 2020 - Elsevier
Xanthine oxidase (XO) is a critical target for the therapy of hyperuricemia and gout. In this
study, a number of 3-[4-alkoxy-3-(1 H-tetrazol-1-yl) phenyl]-1, 2, 4-oxadiazol-5 (4H)-ones (3a …

Melamine–Barbiturate Supramolecular Assembly as a pH‐Dependent Organic Radical Trap Material

VV Shilovskikh, AA Timralieva… - … A European Journal, 2020 - Wiley Online Library
In the last two decades, a large number of self‐assembled materials were synthesized and
they have already found their way into large‐scale industry and science. Hydrogen‐bond …