Regulation of inflammation by the antioxidant haem oxygenase 1
NK Campbell, HK Fitzgerald, A Dunne - Nature Reviews Immunology, 2021 - nature.com
Abstract Haem oxygenase 1 (HO-1), an inducible enzyme responsible for the breakdown of
haem, is primarily considered an antioxidant, and has long been overlooked by …
haem, is primarily considered an antioxidant, and has long been overlooked by …
Heme oxygenase-1: an anti-inflammatory effector in cardiovascular, lung, and related metabolic disorders
SW Ryter - Antioxidants, 2022 - mdpi.com
The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO),
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …
Oxidative stress and inflammation in acute and chronic lung injuries
FS Bezerra, M Lanzetti, RT Nesi, AC Nagato, CP Silva… - Antioxidants, 2023 - mdpi.com
Acute and chronic lung injuries are among the leading causes of mortality worldwide. Lung
injury can affect several components of the respiratory system, including the airways …
injury can affect several components of the respiratory system, including the airways …
Acute respiratory distress syndrome
MA Matthay, RL Zemans, GA Zimmerman… - Nature reviews Disease …, 2019 - nature.com
The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …
Antioxidant effects of statins by modulating Nrf2 and Nrf2/HO-1 signaling in different diseases
A Mansouri, Ž Reiner, M Ruscica… - Journal of Clinical …, 2022 - mdpi.com
Statins are competitive inhibitors of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and
have been used to treat elevated low-density lipoprotein cholesterol (LDL-C) for almost four …
have been used to treat elevated low-density lipoprotein cholesterol (LDL-C) for almost four …
The therapeutic potential of carbon monoxide
R Motterlini, LE Otterbein - Nature reviews Drug discovery, 2010 - nature.com
Carbon monoxide (CO) is increasingly being accepted as a cytoprotective and homeostatic
molecule with important signalling capabilities in physiological and pathophysiological …
molecule with important signalling capabilities in physiological and pathophysiological …
Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation
SW Ryter, AMK Choi - Translational Research, 2016 - Elsevier
The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …
The targets of curcumin
H Zhou, CS Beevers, S Huang - Current drug targets, 2011 - ingentaconnect.com
Curcumin (diferuloylmethane), an orange-yellow component of turmeric or curry powder, is a
polyphenol natural product isolated from the rhizome of the plant Curcuma longa. For …
polyphenol natural product isolated from the rhizome of the plant Curcuma longa. For …
[HTML][HTML] Phycocyanin: Anti-inflammatory effect and mechanism
R Liu, S Qin, W Li - Biomedicine & Pharmacotherapy, 2022 - Elsevier
As the host defense response to various injuries and pathogens in the body, inflammation
can remove damaged cells and pathogens in the host organism and protect the body …
can remove damaged cells and pathogens in the host organism and protect the body …
Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications
SW Ryter, J Alam, AMK Choi - Physiological reviews, 2006 - journals.physiology.org
The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …