Targeting the signaling in Epstein–Barr virus-associated diseases: Mechanism, regulation, and clinical study

Y Cao, L Xie, F Shi, M Tang, Y Li, J Hu, L Zhao… - Signal transduction and …, 2021 - nature.com
Epstein–Barr virus-associated diseases are important global health concerns. As a group I
carcinogen, EBV accounts for 1.5% of human malignances, including both epithelial-and …

Novel therapeutics for Epstein–Barr virus

G Andrei, E Trompet, R Snoeck - Molecules, 2019 - mdpi.com
Epstein–Barr virus (EBV) is a human γ-herpesvirus that infects up to 95% of the adult
population. Primary EBV infection usually occurs during childhood and is generally …

Antiviral drugs for EBV

JS Pagano, CB Whitehurst, G Andrei - Cancers, 2018 - mdpi.com
Epstein–Barr virus (EBV) infects up to 95% of the adult human population, with primary
infection typically occurring during childhood and usually asymptomatic. However, EBV can …

[HTML][HTML] Unexpected patterns of Epstein–Barr virus transcription revealed by a high throughput PCR array for absolute quantification of viral mRNA

RJ Tierney, CD Shannon-Lowe, L Fitzsimmons, AI Bell… - Virology, 2015 - Elsevier
We have validated a flexible, high-throughput and relatively inexpensive RT-QPCR array
platform for absolute quantification of Epstein–Barr virus transcripts in different latent and …

Suppression of Epstein-Barr virus DNA load in latently infected nasopharyngeal carcinoma cells by CRISPR/Cas9

KS Yuen, ZM Wang, NHM Wong, ZQ Zhang, TF Cheng… - Virus research, 2018 - Elsevier
Epstein-Barr virus (EBV) infects more than 90% of the world's adult population. Once
established, latent infection of nasopharyngeal epithelial cells with EBV is difficult to …

Therapies based on targeting Epstein‐Barr virus lytic replication for EBV‐associated malignancies

H Li, J Hu, X Luo, AM Bode, Z Dong, Y Cao - Cancer Science, 2018 - Wiley Online Library
In recent years, Epstein‐Barr virus (EBV) lytic infection has been shown to significantly
contribute to carcinogenesis. Thus, therapies aimed at targeting the EBV lytic cycle have …

Knockout of Epstein-Barr virus BPLF1 retards B-cell transformation and lymphoma formation in humanized mice

CB Whitehurst, G Li, SA Montgomery, ND Montgomery… - MBio, 2015 - Am Soc Microbiol
ABSTRACT BPLF1 of Epstein-Barr virus (EBV) is classified as a late lytic cycle protein but is
also found in the viral tegument, suggesting its potential involvement at both initial and late …

Management of Cytomegalovirus Infections in the Era of the Novel Antiviral Players, Letermovir and Maribavir

J Piret, G Boivin - Infectious Disease Reports, 2024 - mdpi.com
Cytomegalovirus (CMV) infections may increase morbidity and mortality in
immunocompromised patients. Until recently, standard antiviral drugs against CMV were …

Spectrum of activity and mechanisms of resistance of various nucleoside derivatives against gammaherpesviruses

N Coen, S Duraffour, D Topalis… - Antimicrobial Agents …, 2014 - Am Soc Microbiol
The susceptibilities of gammaherpesviruses, including Epstein-Barr virus (EBV), Kaposi's
sarcoma-associated herpesvirus (KSHV), and animal rhadinoviruses, to various nucleoside …

The lytic phase of Epstein–Barr virus plays an important role in tumorigenesis

Y Liang, Y Zhang, B Luo - Virus Genes, 2023 - Springer
Epstein–Barr virus (EBV) is a recognized oncogenic virus that is related to the occurrence of
lymphoma, nasopharyngeal carcinoma (NPC), and approximately 10% of gastric cancer …