Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy

A Vezzani, S Balosso, T Ravizza - Nature Reviews Neurology, 2019 - nature.com
Epilepsy is a chronic neurological disease characterized by an enduring propensity for
generation of seizures. The pathogenic processes of seizure generation and recurrence are …

Neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies

EA van Vliet, E Aronica, A Vezzani… - Neuropathology and …, 2018 - Wiley Online Library
Accumulating evidence indicates an important pathophysiological role of brain inflammation
in epilepsy. In this review, we will provide an update of specific inflammatory pathways that …

Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management

C Rawat, S Kukal, UR Dahiya, R Kukreti - Journal of neuroinflammation, 2019 - Springer
Epilepsy, a common multifactorial neurological disease, affects about 69 million people
worldwide constituting nearly 1% of the world population. Despite decades of extensive …

Efficacy and safety of NSAIDs in infants: a comprehensive review of the literature of the past 20 years

VC Ziesenitz, T Welzel, M van Dyk, P Saur, M Gorenflo… - Pediatric Drugs, 2022 - Springer
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in infants, children, and
adolescents worldwide; however, despite sufficient evidence of the beneficial effects of …

New vascular classification of port‐wine stains: improving prediction of Sturge–Weber risk

R Waelchli, SE Aylett, K Robinson… - British Journal of …, 2014 - academic.oup.com
Background Facial port‐wine stains (PWSs) are usually isolated findings; however, when
associated with cerebral and ocular vascular malformations they form part of the classical …

Updates on sturge-weber syndrome

SE Yeom, AM Comi - Stroke, 2022 - Am Heart Assoc
Sturge-Weber syndrome (SWS) is a rare, noninherited neurovascular disorder characterized
by abnormal vasculature in the brain, skin, and eye. Patients with SWS characteristically …

Pediatric arterial ischemic stroke: Epidemiology, risk factors, and management

RJ Felling, LR Sun, EC Maxwell, N Goldenberg… - Blood Cells, Molecules …, 2017 - Elsevier
Pediatric arterial ischemic stroke (AIS) is an uncommon but important cause of neurologic
morbidity in neonates and children, with consequences including hemiparesis, intellectual …

Sturge–Weber syndrome: from the past to the present

A Sudarsanam, SL Ardern-Holmes - European Journal of Paediatric …, 2014 - Elsevier
Sturge–Weber syndrome is a rare sporadic neurocutaneous syndrome the hallmark of which
is a facial port-wine stain involving the first division of the trigeminal nerve, ipsilateral …

Current therapeutic options in Sturge-Weber syndrome

A Comi - Seminars in pediatric neurology, 2015 - Elsevier
Sturge-Weber syndrome is a vascular malformation syndrome consisting of a facial port-
wine birthmark associated with malformed leptomeningeal blood vessels and a choroid …

Therapeutic role of targeting mTOR signaling and neuroinflammation in epilepsy

SL Hodges, JN Lugo - Epilepsy research, 2020 - Elsevier
Existing therapies for epilepsy are primarily symptomatic and target mechanisms of neuronal
transmission in order to restore the excitatory/inhibitory imbalance in the brain after seizures …