Ion mobility mass spectrometry in the omics era: Challenges and opportunities for metabolomics and lipidomics

G Paglia, AJ Smith, G Astarita - Mass Spectrometry Reviews, 2022 - Wiley Online Library
Researchers worldwide are taking advantage of novel, commercially available,
technologies, such as ion mobility mass spectrometry (IM‐MS), for metabolomics and …

Different ion mobility‐mass spectrometry coupling techniques to promote metabolomics

A Delvaux, E Rathahao‐Paris… - Mass Spectrometry …, 2022 - Wiley Online Library
Metabolomics has become increasingly popular in recent years for many applications
ranging from clinical diagnosis, human health to biotechnological questioning. Despite …

Resolution of isomeric mixtures in ion mobility using a combined demultiplexing and peak deconvolution technique

JC May, R Knochenmuss, JC Fjeldsted… - Analytical …, 2020 - ACS Publications
A combined data acquisition and data processing strategy for improving the sensitivity and
resolution of ion mobility measurements is described. This strategy is implemented on a …

Conformational landscapes of ubiquitin, cytochrome c, and myoglobin: Uniform field ion mobility measurements in helium and nitrogen drift gas

JC May, E Jurneczko, SM Stow, I Kratochvil… - International journal of …, 2018 - Elsevier
In this study, a commercial uniform field drift tube ion mobility-mass spectrometer (IM-MS)
was utilized to measure the gas-phase conformational populations of three well-studied …

Development of a new ion mobility time-of-flight mass spectrometer

YM Ibrahim, ES Baker, WF Danielson III… - International journal of …, 2015 - Elsevier
A new ion mobility spectrometer (IMS) platform was developed to improve upon the
sensitivity and reproducibility of our previous platforms, and further enhance IMS–MS utility …

Using skyline to analyze data-containing liquid chromatography, ion mobility spectrometry, and mass spectrometry dimensions

BX MacLean, BS Pratt, JD Egertson… - Journal of The …, 2018 - ACS Publications
Recent advances in ion mobility spectrometry (IMS) have illustrated its power in determining
the structural characteristics of a molecule, especially when coupled with other separations …

LipidIMMS Analyzer: integrating multi-dimensional information to support lipid identification in ion mobility—mass spectrometry based lipidomics

Z Zhou, X Shen, X Chen, J Tu, X Xiong, ZJ Zhu - Bioinformatics, 2019 - academic.oup.com
Ion mobility—mass spectrometry (IM-MS) has showed great application potential for
lipidomics. However, IM-MS based lipidomics is significantly restricted by the available …

Computational tools and algorithms for ion mobility spectrometry‐mass spectrometry

DH Ross, H Bhotika, X Zheng, RD Smith… - …, 2024 - Wiley Online Library
Ion mobility spectrometry‐mass spectrometry (IMS‐MS or IM‐MS) is a powerful analytical
technique that combines the gas‐phase separation capabilities of IM with the identification …

DEIMoS: an open-source tool for processing high-dimensional mass spectrometry data

SM Colby, CH Chang, JL Bade, JR Nunez… - Analytical …, 2022 - ACS Publications
We present DEIMoS: Data Extraction for Integrated Multidimensional Spectrometry, a Python
application programming interface (API) and command-line tool for high-dimensional mass …

Theoretical evaluation of peak capacity improvements by use of liquid chromatography combined with drift tube ion mobility-mass spectrometry

TJ Causon, S Hann - Journal of Chromatography A, 2015 - Elsevier
In the domain of liquid phase separations, the quality of separation obtainable is most
readily gauged by consideration of classical chromatographic peak capacity theory. Column …