Many species of ganglioside GM1, differing for the sialic acid and ceramide content, have
been characterized and their physico-chemical properties have been studied in detail since …

Lipid rafts are small, dynamic membrane areas characterized by the clustering of selected
membrane lipids as the result of the spontaneous separation of glycolipids, sphingolipids …

Multiple sclerosis (MS) represents the most common demyelinating disease affecting the
central nervous system (CNS) in adults as well as in children. Furthermore, in children, in …

Sphingolipids are a structural component of the cell membrane, derived from sphingosine,
an amino alcohol. Its sphingoid base undergoes various types of enzymatic transformations …

Abstract Niemann-Pick type C (NPC) disease is a lysosomal storage disorder resulting from
mutations in either the NPC1 (95%) or NPC2 (5%) genes. NPC typically presents in …

For many decades, research on sphingolipids associated with neurodegenerative disease
focused on alterations in glycosphingolipids, particularly glycosylceramides (cerebrosides) …

Single-cell measurements aid our understanding of chemically heterogeneous systems
such as the brain. Lipids are one of the least studied chemical classes, and their cell-to-cell …

Sphingolipid dysregulation is often associated with insulin resistance, while the enzymes
controlling sphingolipid metabolism are emerging as therapeutic targets for improving …

In recent years, research on sphingolipids, particularly ceramides, has attracted increased
attention, revealing the important roles and many functions of these molecules in several …

Abstract Sphingosine-1-phosphate lyase (SPL) is an intracellular enzyme that controls the
final step in the sphingolipid degradative pathway, the only biochemical pathway for removal …