The utility of induced pluripotent stem (iPS) cells for investigating the molecular logic of
pluripotency and for eventual clinical application is limited by the low efficiency of current …

Cell type-specific gene expression patterns are outputs of transcriptional gene regulatory
networks (GRNs) that connect transcription factors and signaling proteins to target genes …

Generation of induced pluripotent stem (iPS) cells holds a great promise for regenerative
medicine and other aspects of clinical applications. Many types of cells have been …

Stem cell is defined by its ability to self-renewal and generates differentiated functional cell
types, which are derived from the embryo and various sources of postnatal animal. These …

Differentiation from a multipotent stem or progenitor state to a mature cell is an essentially
irreversible process. The associated changes in gene expression patterns exhibit time …

Somatic reprogramming to induced pluripotent stem cells (iPSC) was realized in the year
2006 in mice, and in 2007 in humans, by transiently forced expression of a combination of …

The concept of epigenetics has been known about since the 1940s, but it is only in the last
10 years that research has shown just how wide ranging its effects are. It is now a very …

Practical clinical applications for current induced pluripotent stem cell (iPSC) technologies
are hindered by very low generation efficiencies. Here, we demonstrate that newborn …

The oocyte-independent source for the generation of pluripotent stem cells is among the
ultimate goals in regenerative medicine. We report that on exposure to mouse embryonic …

With relatively low efficiency, differentiated cells can be reprogrammed to a pluripotent state
by ectopic expression of a few transcription factors. An understanding of the mechanisms …