Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …

Extracellular adenine nucleotides play important roles in cell–cell communication and tissue
homeostasis. High concentrations of extracellular ATP released by dying cells are sensed …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

This review article provides a historical perspective on the role of purinergic signalling in the
regulation of various subsets of immune cells from early discoveries to current …

Purinergic P2X7 receptor, a nonselective cation channel, is highly expressed in immune
cells as well as cardiac smooth muscle cells and endothelial cells. Its activation exhibits to …

Extracellular purinergic products, particularly ATP, have recently been implicated to regulate
immune cell functions and contribute to aberrant inflammatory responses of immune …

Multiple sclerosis (MS) is characterized by macrophage accumulation and inflammatory
infiltrates into the CNS contributing to demyelination. Because purinergic P2X7 receptor …

Alternative splicing (AS) tremendously increases the use of genetic information by
generating protein isoforms that differ in protein–protein interactions, catalytic activity and/or …

The P2X7 receptor is an ATP-gated cation channel expressed by a number of cell types. We
have shown previously that disruption of P2X7 receptor function results in downregulation of …

The formate-nitrite transporters (FNTs) represent a widespread family of membrane proteins
involved in the translocation of monovalent polyatomic anions, such as formate, nitrite and …