Network medicine in the age of biomedical big data

AR Sonawane, ST Weiss, K Glass, A Sharma - Frontiers in Genetics, 2019 - frontiersin.org
Network medicine is an emerging area of research dealing with molecular and genetic
interactions, network biomarkers of disease, and therapeutic target discovery. Large-scale …

Comparative pathology of human and canine myxomatous mitral valve degeneration: 5HT and TGF-β mechanisms

MA Oyama, C Elliott, KA Loughran, AP Kossar… - Cardiovascular …, 2020 - Elsevier
Myxomatous mitral valve degeneration (MMVD) is a leading cause of valve repair or
replacement secondary to the production of mitral regurgitation, cardiac enlargement …

Targeting 5-HT2B Receptor Signaling Prevents Border Zone Expansion and Improves Microstructural Remodeling After Myocardial Infarction

JC Snider, LA Riley, NT Mallory, MR Bersi… - Circulation, 2021 - Am Heart Assoc
Background: Myocardial infarction (MI) induces an intense injury response that ultimately
generates a collagen-dominated scar. Although required to prevent ventricular rupture, the …

Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation

E Castillero, E Fitzpatrick, SJ Keeney… - Science translational …, 2023 - science.org
Degenerative mitral valve (MV) regurgitation (MR) is a highly prevalent heart disease that
requires surgery in severe cases. Here, we show that a decrease in the activity of the …

Development of Pharmacophore Models for the Important Off-Target 5-HT2B Receptor

S Schieferdecker, E Vock - Journal of Medicinal Chemistry, 2023 - ACS Publications
Toxicity is a major cause of attrition in the development of pharmaceuticals, and the off-target
effects are a frequent contributor. The 5-HT2B receptor agonism is known to be responsible …

[HTML][HTML] Mechanical strain induces a pro-fibrotic phenotype in human mitral valvular interstitial cells through RhoC/ROCK/MRTF-A and Erk1/2 signaling pathways

B Blomme, C Deroanne, A Hulin, C Lambert… - Journal of Molecular and …, 2019 - Elsevier
The mitral valve is a complex multilayered structure populated by fibroblast-like cells,
valvular interstitial cells (VIC) which are embedded in an extracellular matrix (ECM) scaffold …

Update in carcinoid heart disease-the heart of the matter

K Oleinikov, A Korach, D Planer, D Gilon… - Reviews in Endocrine …, 2021 - Springer
Carcinoid heart disease (CHD) is a paraneoplastic cardiac manifestation occurring in
patients with carcinoid syndrome (CS) and advanced neuroendocrine malignancy. In about …

Connections for matters of the heart: network medicine in cardiovascular diseases

AR Sonawane, E Aikawa, M Aikawa - Frontiers in Cardiovascular …, 2022 - frontiersin.org
Cardiovascular diseases (CVD) are diverse disorders affecting the heart and vasculature in
millions of people worldwide. Like other fields, CVD research has benefitted from the deluge …

TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease

AJ McNair, GR Markby, Q Tang, VE MacRae… - Frontiers in Veterinary …, 2023 - frontiersin.org
Background TGFβ signaling appears to contribute to the pathogenesis of myxomatous mitral
valve disease (MMVD) in both dogs and humans. However, little is known about the extent …

Serotonin contribution to cardiac valve degeneration: new insights for novel therapies?

E Ayme-Dietrich, R Lawson, S Da-Silva… - Pharmacological …, 2019 - Elsevier
Heart valve disease (HVD) is a complex entity made by different pathological processes that
ultimately lead to the abnormal structure and disorganization of extracellular matrix proteins …