Nearly 60 CCCH zinc finger proteins have been identified in humans and mice. These
proteins are involved in the regulation of multiple steps of RNA metabolism, including mRNA …

Post-transcriptional regulation is involved in the regulation of many inflammatory genes. Zinc
finger protein 36 (ZFP36) family proteins are RNA-binding proteins involved in messenger …

Ferroptosis is a recently discovered form of programmed cell death, but its regulatory
mechanisms remain poorly understood. Here, we show that the RNA-binding protein …

Impairment of translation can lead to collisions of ribosomes, which constitute an activation
platform for several ribosomal stress-surveillance pathways. Among these is the ribotoxic …

N6-methyladenosine (m6A) is an abundant mRNA modification that affects multiple
biological processes, including those involved in the cell stress response and viral infection …

Abstract Receptor-interacting protein kinase-1 (RIPK1), a master regulator of cell fate
decisions, was identified as a direct substrate of MAPKAP kinase-2 (MK2) by …

Esophageal squamous cell carcinoma (ESCC) is prevalent in some geographical regions of
the world. ESCC development presents a multistep pathogenic process from inflammation to …

RNA-binding proteins (RBPs) are essential for the development and function of the immune
system. They interact dynamically with RNA to control its biogenesis and turnover by …

Impairment of ribosome function activates the MAPKKK ZAK, leading to activation of mitogen-
activated protein (MAP) kinases p38 and JNK and inflammatory signaling. The mechanistic …

Dynamic post-transcriptional control of RNA expression by RNA-binding proteins (RBPs) is
critical during immune response. ZFP36 RBPs are prominent inflammatory regulators linked …