Late-Stage Modification of Peptides with Maleimides through Palladium-Catalyzed β-C(sp3)–H Alkylation
F Lu, Y Geng, H Wang, Y Liu, E Zhang, L Yang… - Organic …, 2024 - ACS Publications
Transition-metal-catalyzed C–H activation has proven to be a powerful tool for the late-stage
modification of peptides. We herein report a method for site-selective alkylation of peptides …
modification of peptides. We herein report a method for site-selective alkylation of peptides …
Synthetic approach of hydroxy-acetophenone-directed Rh (III) catalyzed CH o-alkylation via 1, 4 addition: Insights from DFT and docking methodology
P Sivakumar, PSKP Ganesh, P Muthuraja… - Journal of Molecular …, 2024 - Elsevier
This study presents a Rh (III)-catalyzed 1, 4-addition approach, utilizing a directing group to
functionalize the o-carbon of ester-containing acetophenone groups with maleimides …
functionalize the o-carbon of ester-containing acetophenone groups with maleimides …