Premature infants are exposed to increased generation of reactive oxygen species, and on
the other hand, they have a deficient antioxidant defense system. Oxidative insult is a salient …

The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …

In the pulmonary vasculature, the endothelial and smooth muscle cells are two key cell types
that play a major role in the pathobiology of pulmonary vascular disease and pulmonary …

Inhaled nitric oxide (iNO) is approved for use in persistent pulmonary hypertension of the
newborn (PPHN) but does not lead to sustained improvement in oxygenation in one-third of …

Oxidative stress can be associated with hyperoxia and hypoxia and is characterized by an
increase in reactive oxygen (ROS) and nitrogen (RNS) species generated by an underlying …

The fetal circulation uses a series of adaptive mechanisms to maximize delivery of oxygen to
the most metabolically active tissues. Blood returning from the placenta through the …

Significance: Pulmonary hypertension is a devastating disorder without any available
treatment strategies that satisfactorily promote the survival of patients. The identification of …

The consequences of most hernias can be immediately corrected by surgical repair.
However, this isn't always the case for children born with a congenital diaphragmatic hernia …

Autophagy is a process for cells to degrade proteins or entire organelles to maintain a
balance in the synthesis, degradation, and subsequent recycling of cellular products …

Effective ventilation of the lungs is essential in mediating pulmonary vasodilation at birth to
allow effective gas exchange and an increase in systemic oxygenation. Unsuccessful …