Abstract Cytochrome 450 (CYP450) designates a group of enzymes abundant in smooth
endoplasmic reticulum of hepatocytes and epithelial cells of small intestines. The main …

Multiple genes have been studied for potential associations with lung cancer. The gene
most frequently associated with increased risk has been glutathione S-transferase M1 …

There is wide variability in the response of individuals to standard doses of drug therapy.
This is an important problem in clinical practice, where it can lead to therapeutic failures or …

Background Glutathione S-transferases (GSTs) are known to abolish or reduce the activities
of intracellular enzymes that help detoxify environmental carcinogens, such as those found …

Lung cancer is the most common malignancy in the Western world, and the main risk factor
is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated …

Phase I and II drug metabolizing enzymes (DME) and drug transporters are involved in the
absorption, distribution, metabolism as well as elimination of many therapeutic agents …

Susceptibility to lung cancer has been shown to be modulated by inheritance of polymorphic
genes encoding cytochrome P450 1A1 (CYP1A1) and glutathione S transferases (GSTM1 …

В монографии обобщены современные данные о метаболических механизмах
функционирования клеток иммунной системы при различных иммунопатологических …

The Kashmir Valley has an elevated incidence rate of esophageal cancer (EC). Several
environmental and genetic factors have been suspected for development of EC. A case …

Background Many studies have examined the association between the CYP1A1 MspI and
exon 7 gene polymorphisms and lung cancer risk in various populations, but their results …