BACKGROUND Recent progress in the formation of artificial gametes, ie gametes generated
by manipulation of their progenitors or of somatic cells, has led to scientific and societal …

In vitro gametogenesis (IVG) might offer numerous research and clinical benefits. Some
potential clinical applications of IVG, such as allowing opposite‐sex couples experiencing …

Objective Recapitulation of the spermatogenesis process in vitro is a tool for studying the
biology of germ cells, and may lead to promising therapeutic strategies in the future. In this …

Contents Mesenchymal stem cells (MSC) are multipotent progenitor cells defined by their
ability to self‐renew and give rise to differentiated progeny. Previous studies have reported …

Studies published in recent years have changed the outlook on sterility and germ cell
development by producing gametes from stem cells. In present study, a novel approach on …

In vitro gamete derivation based on differentiation of germ cells (GC) from stem cells has
emerged as a potential new strategy for the treatment of male infertility. This technology also …

Some commentators indirectly challenge the ethics of using synthetic gametes as a way for
same-sex couples to have children with shared genetics. These commentators typically …

Non-obstructive azoospermia is a severe form of male infertility, with limited effective
treatments. Bone marrow mesenchymal stem cells (BMSCs) can differentiate to different cell …

In vitro gamete derivation from stem cells has potential applications in animal reproduction
as an alternative method for the dissemination of elite animal genetics, production of …

Contents Making sperm cells outside the original testicular environment in a culture dish has
been considered for a long time as impossible due to the very complicated process of …