The existence of subpopulations of cells in cancers with increased tumor-initiating capacities
and self-renewal potential, often termed" cancer stem cells," is a much discussed and key …

ABSTRACT DNA methylation is an epigenetic modification critical to normal genome
regulation and development. The vitamin folate is a key source of the one carbon group …

Both genome-wide genetic and epigenetic alterations are fundamentally important for the
development of cancers, but the interdependence of these aberrations is poorly understood …

Ependymomas are common childhood brain tumours that occur throughout the nervous
system, but are most common in the paediatric hindbrain. Current standard therapy …

Epigenetic mechanisms have been proposed to play crucial roles in mammalian
development, but their precise functions are only partially understood. To investigate …

Abstract Knowledge of epigenetic alterations in disease is rapidly increasing owing to the
development of genome-wide techniques for their identification. The ever-growing number …

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer.
Altered epigenetics regulation including DNA hypermethylation by DNA methyltransferase 1 …

Activation of normally silent tissue-specific genes and the resulting cell “identity crisis” are
the unexplored consequences of malignant epigenetic reprogramming. We designed a …

Mutations in the genes encoding isocitrate dehydrogenase, IDH1 and IDH2, have been
reported in gliomas, myeloid leukemias, chondrosarcomas and thyroid cancer. We …

Nearly all deaths caused by solid cancers occur as a result of metastasis—the formation of
secondary tumours in distant organs such as the lungs, liver, brain and bone. A major …