Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance
H Easwaran, HC Tsai, SB Baylin - Molecular cell, 2014 - cell.com
The existence of subpopulations of cells in cancers with increased tumor-initiating capacities
and self-renewal potential, often termed" cancer stem cells," is a much discussed and key …
and self-renewal potential, often termed" cancer stem cells," is a much discussed and key …
[HTML][HTML] Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role
KS Crider, TP Yang, RJ Berry, LB Bailey - Advances in nutrition, 2012 - Elsevier
ABSTRACT DNA methylation is an epigenetic modification critical to normal genome
regulation and development. The vitamin folate is a key source of the one carbon group …
regulation and development. The vitamin folate is a key source of the one carbon group …
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
Both genome-wide genetic and epigenetic alterations are fundamentally important for the
development of cancers, but the interdependence of these aberrations is poorly understood …
development of cancers, but the interdependence of these aberrations is poorly understood …
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
Ependymomas are common childhood brain tumours that occur throughout the nervous
system, but are most common in the paediatric hindbrain. Current standard therapy …
system, but are most common in the paediatric hindbrain. Current standard therapy …
Epigenomic analysis of multilineage differentiation of human embryonic stem cells
Epigenetic mechanisms have been proposed to play crucial roles in mammalian
development, but their precise functions are only partially understood. To investigate …
development, but their precise functions are only partially understood. To investigate …
DNA methylation profiling in the clinic: applications and challenges
H Heyn, M Esteller - Nature Reviews Genetics, 2012 - nature.com
Abstract Knowledge of epigenetic alterations in disease is rapidly increasing owing to the
development of genome-wide techniques for their identification. The ever-growing number …
development of genome-wide techniques for their identification. The ever-growing number …
Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers
S Rousseaux, A Debernardi, B Jacquiau… - Science translational …, 2013 - science.org
Activation of normally silent tissue-specific genes and the resulting cell “identity crisis” are
the unexplored consequences of malignant epigenetic reprogramming. We designed a …
the unexplored consequences of malignant epigenetic reprogramming. We designed a …
Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas
Mutations in the genes encoding isocitrate dehydrogenase, IDH1 and IDH2, have been
reported in gliomas, myeloid leukemias, chondrosarcomas and thyroid cancer. We …
reported in gliomas, myeloid leukemias, chondrosarcomas and thyroid cancer. We …
DNMT1: A key drug target in triple-negative breast cancer
KK Wong - Seminars in cancer biology, 2021 - Elsevier
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer.
Altered epigenetics regulation including DNA hypermethylation by DNA methyltransferase 1 …
Altered epigenetics regulation including DNA hypermethylation by DNA methyltransferase 1 …
Strategies for the discovery and development of therapies for metastatic breast cancer
BL Eckhardt, PA Francis, BS Parker… - Nature reviews Drug …, 2012 - nature.com
Nearly all deaths caused by solid cancers occur as a result of metastasis—the formation of
secondary tumours in distant organs such as the lungs, liver, brain and bone. A major …
secondary tumours in distant organs such as the lungs, liver, brain and bone. A major …