Integrins can alter cellular behavior through the recruitment and activation of signaling
proteins such as non-receptor tyrosine kinases including focal adhesion kinase (FAK) and c …

Focal-adhesion kinase (FAK) is an important mediator of growth-factor signalling, cell
proliferation, cell survival and cell migration. Given that the development of malignancy is …

Optogenetic and chemogenetic control of proteins has revealed otherwise inaccessible
facets of signaling dynamics. Here, we use light-or ligand-sensitive domains to modulate the …

Tumors are complex cellular and acellular environments within which cancer clones are
under continuous selection pressures. Cancer cells are in a permanent mode of interaction …

Src is a non‐receptor cytoplasmic tyrosine kinase which becomes activated following the
stimulation of plasma membrane receptors including receptor tyrosine kinases and integrins …

Disorders of the central nervous system (CNS) are some of the most prevalent, devastating
and yet poorly treated illnesses. The development of new therapies for CNS disorders such …

Src kinase controls cellular adhesions, including cadherin-based intercellular adhesions
and integrin-mediated cell–matrix adhesions. In epithelial cells, Src activation, or increased …

Focal adhesion kinase (FAK) and steroid receptor coactivator (Src) are intracellular
(nonreceptor) tyrosine kinases that physically and functionally interact to promote a variety of …

Focal adhesion kinase (FAK) is a non‐receptor cytoplasmic tyrosine kinase that plays a key
role in the regulation of proliferation and migration of normal and tumor cells. FAK …

Protein phosphorylation participates in the regulation of all fundamental biological
processes, and protein kinases have been intensively studied. However, while the focus …