[HTML][HTML] Neurotransmitters—key factors in neurological and neurodegenerative disorders of the central nervous system

RI Teleanu, AG Niculescu, E Roza… - International journal of …, 2022 - mdpi.com
Neurotransmitters are molecules that amplify, transmit, and convert signals in cells, having
an essential role in information transmission throughout the nervous system. Hundreds of …

Glia: a major player in glutamate–GABA dysregulation‐mediated neurodegeneration

A Sood, K Preeti, V Fernandes… - Journal of …, 2021 - Wiley Online Library
The imbalance between glutamate and γ‐aminobutyric acid (GABA) results in the loss of
synaptic strength leading to neurodegeneration. The dogma on the field considered neurons …

[HTML][HTML] GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation

S Kang, L Liu, T Wang, M Cannon, P Lin, TWM Fan… - Nature …, 2022 - nature.com
Abstract γ-Aminobutyrate (GAB), the biochemical form of (GABA) γ-aminobutyric acid,
participates in shaping physiological processes, including the immune response. How GAB …

The immunomodulatory roles of the gut microbiome in autoimmune diseases of the central nervous system: multiple sclerosis as a model

K Hoffman, Z Brownell, WJ Doyle… - Journal of autoimmunity, 2023 - Elsevier
The gut-associated lymphoid tissue is a primary activation site for immune responses to
infection and immunomodulation. Experimental evidence using animal disease models …

Nutritional modulation of the intestinal microbiota; future opportunities for the prevention and treatment of neuroimmune and neuroinflammatory disease

VC Lombardi, KL De Meirleir, K Subramanian… - The Journal of nutritional …, 2018 - Elsevier
The gut–brain axis refers to the bidirectional communication between the enteric nervous
system and the central nervous system. Mounting evidence supports the premise that the …

[HTML][HTML] Quantifying the Metabolic Signature of Multiple Sclerosis by in vivo Proton Magnetic Resonance Spectroscopy: Current Challenges and Future Outlook in the …

KM Swanberg, K Landheer, D Pitt, C Juchem - Frontiers in Neurology, 2019 - frontiersin.org
Proton magnetic resonance spectroscopy (1H-MRS) offers a growing variety of methods for
querying potential diagnostic biomarkers of multiple sclerosis in living central nervous …

Multiple sclerosis biomarker discoveries by proteomics and metabolomics approaches

A Jafari, A Babajani, M Rezaei-Tavirani - Biomarker Insights, 2021 - journals.sagepub.com
Multiple sclerosis (MS) is an autoimmune inflammatory disorder of the central nervous
system (CNS) resulting in demyelination and axonal loss in the brain and spinal cord. The …

The role of the gut microbiota and microbial metabolites in neuroinflammation

S Haase, N Wilck, A Haghikia, R Gold… - European Journal of …, 2020 - Wiley Online Library
Recent literature indicates a potential importance of the gut microbiota for immune‐mediated
diseases. For instance, decreased diversity of commensals or an outgrowth of some …

Oligodendrocyte differentiation and myelination is potentiated via GABAB receptor activation

MP Serrano-Regal, I Luengas-Escuza… - Neuroscience, 2020 - Elsevier
Differentiation of oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes (OLs)
is a key event for axonal myelination in the central nervous system (CNS). Several growth …

[HTML][HTML] Inflammation-associated synaptic alterations as shared threads in depression and multiple sclerosis

A Bruno, E Dolcetti, FR Rizzo, D Fresegna… - Frontiers in Cellular …, 2020 - frontiersin.org
In the past years, several theories have been advanced to explain the pathogenesis of Major
Depressive Disorder (MDD), a neuropsychiatric disease that causes disability in general …