[HTML][HTML] Neurotransmitters—key factors in neurological and neurodegenerative disorders of the central nervous system
Neurotransmitters are molecules that amplify, transmit, and convert signals in cells, having
an essential role in information transmission throughout the nervous system. Hundreds of …
an essential role in information transmission throughout the nervous system. Hundreds of …
Glia: a major player in glutamate–GABA dysregulation‐mediated neurodegeneration
The imbalance between glutamate and γ‐aminobutyric acid (GABA) results in the loss of
synaptic strength leading to neurodegeneration. The dogma on the field considered neurons …
synaptic strength leading to neurodegeneration. The dogma on the field considered neurons …
[HTML][HTML] GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation
Abstract γ-Aminobutyrate (GAB), the biochemical form of (GABA) γ-aminobutyric acid,
participates in shaping physiological processes, including the immune response. How GAB …
participates in shaping physiological processes, including the immune response. How GAB …
The immunomodulatory roles of the gut microbiome in autoimmune diseases of the central nervous system: multiple sclerosis as a model
K Hoffman, Z Brownell, WJ Doyle… - Journal of autoimmunity, 2023 - Elsevier
The gut-associated lymphoid tissue is a primary activation site for immune responses to
infection and immunomodulation. Experimental evidence using animal disease models …
infection and immunomodulation. Experimental evidence using animal disease models …
Nutritional modulation of the intestinal microbiota; future opportunities for the prevention and treatment of neuroimmune and neuroinflammatory disease
VC Lombardi, KL De Meirleir, K Subramanian… - The Journal of nutritional …, 2018 - Elsevier
The gut–brain axis refers to the bidirectional communication between the enteric nervous
system and the central nervous system. Mounting evidence supports the premise that the …
system and the central nervous system. Mounting evidence supports the premise that the …
[HTML][HTML] Quantifying the Metabolic Signature of Multiple Sclerosis by in vivo Proton Magnetic Resonance Spectroscopy: Current Challenges and Future Outlook in the …
Proton magnetic resonance spectroscopy (1H-MRS) offers a growing variety of methods for
querying potential diagnostic biomarkers of multiple sclerosis in living central nervous …
querying potential diagnostic biomarkers of multiple sclerosis in living central nervous …
Multiple sclerosis biomarker discoveries by proteomics and metabolomics approaches
Multiple sclerosis (MS) is an autoimmune inflammatory disorder of the central nervous
system (CNS) resulting in demyelination and axonal loss in the brain and spinal cord. The …
system (CNS) resulting in demyelination and axonal loss in the brain and spinal cord. The …
The role of the gut microbiota and microbial metabolites in neuroinflammation
S Haase, N Wilck, A Haghikia, R Gold… - European Journal of …, 2020 - Wiley Online Library
Recent literature indicates a potential importance of the gut microbiota for immune‐mediated
diseases. For instance, decreased diversity of commensals or an outgrowth of some …
diseases. For instance, decreased diversity of commensals or an outgrowth of some …
Oligodendrocyte differentiation and myelination is potentiated via GABAB receptor activation
MP Serrano-Regal, I Luengas-Escuza… - Neuroscience, 2020 - Elsevier
Differentiation of oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes (OLs)
is a key event for axonal myelination in the central nervous system (CNS). Several growth …
is a key event for axonal myelination in the central nervous system (CNS). Several growth …
[HTML][HTML] Inflammation-associated synaptic alterations as shared threads in depression and multiple sclerosis
A Bruno, E Dolcetti, FR Rizzo, D Fresegna… - Frontiers in Cellular …, 2020 - frontiersin.org
In the past years, several theories have been advanced to explain the pathogenesis of Major
Depressive Disorder (MDD), a neuropsychiatric disease that causes disability in general …
Depressive Disorder (MDD), a neuropsychiatric disease that causes disability in general …