The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment
of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic …

Mechanical forces are central to how cancer treatments such as chemotherapeutics and
immunotherapies interact with cells and tissues. At the simplest level, electrostatic forces …

Cells cultured in 3D fibrous biopolymer matrices exert traction forces on their environment
that induce deformations and remodeling of the fiber network. By measuring these …

Collagen fibers in the 3D tumor microenvironment (TME) exhibit complex alignment
landscapes that are critical in directing cell migration through a process called contact …

Matrix metalloproteinase-9 (MMP-9), a proteolytic enzyme, degrades the extracellular matrix
and plays a key role in cell communication. However, the real-time monitoring of cell …

During mitosis, cells round up and utilize the interphase adhesion sites within the fibrous
extracellular matrix (ECM) as guidance cues to orient the mitotic spindles. Here, using …

Cytoskeleton‐mediated force transmission regulates nucleus morphology. How nuclei
shaping occurs in fibrous in vivo environments remains poorly understood. Here suspended …

Leader cells direct collective migration through sensing cues in their microenvironment to
determine migration direction. The mechanism by which leader cells sense the mechanical …

As fibrous collagen is the most abundant protein in mammalian tissues, gels of collagen
fibers have been extensively used as an extracellular matrix scaffold to study how cells …

Fibrous hydrogels are a key component of soft animal tissues. They support cellular
functions and facilitate efficient mechanical communication between cells. Due to their …