Muscle atrophy and decline in muscle strength appear very rapidly with prolonged disuse or
mechanical unloading after acute hospitalization or experimental bed rest. The current study …

Mammalian skeletal muscle shows an enormous variability in its functional features such as
rate of force production, resistance to fatigue, and energy metabolism, with a wide spectrum …

Spastic paresis follows chronic disruption of the central execution of volitional command.
Motor function in patients with spastic paresis is subjected over time to three fundamental …

Bed rest studies of the past 20 years are reviewed. Head-down bed rest (HDBR) has proved
its usefulness as a reliable simulation model for the most physiological effects of spaceflight …

Muscle strength and, to a greater extent, power inexorably decline with ageing. Quantitative
loss of muscle mass, referred to as “sarcopenia”, is the most important factor underlying this …

Skeletal muscle shows an enormous plasticity to adapt to stimuli such as contractile activity
(endurance exercise, electrical stimulation, denervation), loading conditions (resistance …

Background Muscle quantity at intensive care unit (ICU) admission has been independently
associated with mortality. In addition to quantity, muscle quality may be important for …

Background: Recent findings suggest that higher levels of intermuscular adipose tissue
(IMAT) are associated with glucose dysregulation, lower levels of muscle strength, and a …

Sarcopenia, the age-related loss of muscle mass and strength, is a fundamental cause of
frailty, functional decline and disability. In the year 2000, $18.5 billion in health care costs …

Background & aims Profound weight loss and malnutrition subsequent to severe dysphagia
and cancer cachexia are cardinal symptoms in oesophageal cancer (OC). Low muscle …