The small GTPase Rac1 has been implicated in a variety of dynamic cell biological
processes, including cell proliferation, cell survival, cell-cell contacts, epithelial …

Rho-GTPases control a variety of cellular functions mainly by regulating microtubule and
actin dynamics, affecting the cytoskeleton, and are important regulators of the structural …

Despite great improvements in the diagnosis and treatment of neoplasms, metastatic
disease is still the leading cause of death in cancer patients, with mortality rates still rising …

Colorectal cancer is one of the major health problems, with invade surrounding tissues, and
migrate to distant organs being the most critical concern, thus identified metastasis …

The aim of this study was to evaluate the clinicopathological significance and associated
signaling pathways of p21-activated kinase 1 (PAK1) in colorectal cancer (CRC). PAK1 …

This study intends to explore the effect of the PAK1 gene silencing on apoptosis and
proliferation of hepatocellular carcinoma (HCC) MHCC97-H and HepG2 cells and cells in …

Relative to several other p21-activated kinase (PAK) family members, the role of PAK3 in
regulating cancer cell functions remains unclear. Our study obtained evidence that PAK3 …

Metastatic prostate cancer (PCa) has a very high mortality rate in men, in Western countries
and lacks reliable treatment. The advanced-stage PCa cells overexpress P21 (RAC1) …

P21-activated kinases (PAKs) are serine/threonine protein kinases that contribute to several
cellular processes. Here, we aimed to determine the prognostic value of PAK1 and its …

Background and study aims Colorectal carcinoma (CRC) is associated with high morbidity
and mortality. The E-cadherin–catenin complex is crucial in the development and …