Complex regulatory networks of virulence factors in Vibrio vulnificus

G Choi, SH Choi - Trends in Microbiology, 2022 - cell.com
The fulminating zoonotic pathogen Vibrio vulnificus is the causative agent of fatal septicemia
in humans and fish, raising tremendous economic burdens in healthcare and the …

Vibrio fischeri: a model for host-associated biofilm formation

BL Fung, JJ Esin, KL Visick - Journal of Bacteriology, 2024 - Am Soc Microbiol
Multicellular communities of adherent bacteria known as biofilms are often detrimental in the
context of a human host, making it important to study their formation and dispersal …

A polysaccharide biosynthesis locus in Vibrio parahaemolyticus important for biofilm formation has homologs widely distributed in aquatic bacteria mainly from …

M Liu, H Nie, X Luo, S Yang, H Chen, P Cai - Msystems, 2022 - Am Soc Microbiol
Vibrio parahaemolyticus is a seafood-borne pathogen that poses a great threat to public
health worldwide. It is found in either a planktonic cell or a biofilm form in the natural …

A Tad pilus promotes the establishment and resistance of Vibrio vulnificus biofilms to mechanical clearance

M Pu, DA Rowe-Magnus - npj Biofilms and Microbiomes, 2018 - nature.com
Vibrio vulnificus is autochthonous to estuaries and warm coastal waters. Infection occurs via
open wounds or ingestion, where its asymptomatic colonization of seafood, most infamously …

PlzD modifies Vibrio vulnificus foraging behavior and virulence in response to elevated c-di-GMP

T Chen, M Pu, S Subramanian, D Kearns… - Mbio, 2023 - Am Soc Microbiol
Some marine bacteria can swim at speeds exceeding 50× their body length per second as
they actively seek out fleeting microscale nutrient patches. Yet, even in vast marine …

The cabABC Operon Essential for Biofilm and Rugose Colony Development in Vibrio vulnificus

JH Park, Y Jo, SY Jang, H Kwon, Y Irie… - PLoS …, 2015 - journals.plos.org
A transcriptome analysis identified Vibrio vulnificus cabABC genes which were preferentially
expressed in biofilms. The cabABC genes were transcribed as a single operon. The cabA …

Two novel genes identified by large-scale transcriptomic analysis are essential for biofilm and rugose colony development of Vibrio vulnificus

H Lee, H Im, SH Hwang, D Ko, SH Choi - PLoS Pathogens, 2023 - journals.plos.org
Many pathogenic bacteria form biofilms to survive under environmental stresses and host
immune defenses. Differential expression (DE) analysis of the genes in biofilm and …

Natural Strain Variation Reveals Diverse Biofilm Regulation in Squid-Colonizing Vibrio fischeri

ER Rotman, KM Bultman, JF Brooks… - Journal of …, 2019 - Am Soc Microbiol
The mutualistic symbiont Vibrio fischeri builds a symbiotic biofilm during colonization of
squid hosts. Regulation of the exopolysaccharide component, termed Syp, has been …

A conserved tad pilus promotes Vibrio vulnificus oyster colonization

M Pu, P Duriez, M Arazi… - Environmental …, 2018 - Wiley Online Library
Vibrio vulnificus has the highest death rate (> 35%) and per‐case economic burden ($3.3
million) of any foodborne pathogen in the United States. Infections occur via open wounds or …

Environmental calcium initiates a feed-forward signaling circuit that regulates biofilm formation and rugosity in Vibrio vulnificus

DM Chodur, P Coulter, J Isaacs, M Pu, N Fernandez… - MBio, 2018 - Am Soc Microbiol
Poor clinical outcomes (disfigurement, amputation, and death) and significant economic
losses in the aquaculture industry can be attributed to the potent opportunistic human …